Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
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Drug Isomer Related Products (557)
Related Products (557)
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α-Thujaplicin
0 Imagesα-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma.
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(Rac)-Centrolobol
0 ImagesCat. No.: HY-N3564ACAS No.: 98119-94-9(Rac)-Centrolobol is a racemic isomer of Centrolobol (HY-N3564). Centrolobol is a diarylheptane compound with antioxidant and anti-inflammatory properties, which exists in the fermented stems of Alnus sibirica. Centrolobol scavenges DPPH free radicals and inhibits the production of NO in LPS-stimulated immune cells. Centrolobol can be used in studies related to anti-inflammation and antioxidation.
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(R)-Ro 15-2041
0 ImagesCat. No.: HY-116650CAS No.: 77378-53-1(R)-Ro 15-2041 is the R-configurational isomer of Ro 15-2041 (HY-101807). Ro 15-2041 is a selective platelet phosphodiesterase inhibitor with antithrombotic properties.
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Tauroisolithocholanoic acid sodium
0 ImagesCat. No.: HY-N15890CAS No.: 2707415-30-1Tauroisolithocholanoic acid sodium is an isomer of the naturally occurring Taurolithocholic acid (HY-113308).
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D-Lysine monohydrochloride (Standard)
0 ImagesD-Lysine monohydrochloride (Standard) is the analytical standard of D-Lysine monohydrochloride (HY-Y1804). This product is intended for research and analytical applications. D-Lysine monohydrochloride is the D-enantiomer of L-Lysine (HY-N0469). D-Lysine monohydrochloride is metabolically inert and not utilized for protein synthesis by mammalian ribosomes. D-Lysine monohydrochloride blocks renal uptake of 111In/90Y-Octreotide (HY-P0036)-based probes without inhibiting uptake by tumor/receptor tissues, and thus acts as a renoprotective agent in diagnostic imaging and peptide receptor radionuclide therapy (PRRT). D-Lysine monohydrochloride specifically inhibits the early steps of non-enzymatic glycation by competing with glucose via its free amino group, theoretically, it can serve as a glycation competitor that "does not interfere with protein synthesis" under chronic hyperglycemia in diabetes. D-Lysine monohydrochloride can be used in research related to cancer and diabetes.
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(2S,5S)-CMI-392
0 ImagesCat. No.: HY-19205BCAS No.: 205654-37-1(2S,5S)-CMI-392 is the absolute configuration of CMI-392 (HY-19205A). CMI-392 is an orally active dual 5-lipoxygenase inhibitor and platelet-activating factor receptor (PAFR) antagonist, with an IC50 of 10 nM for human PAF receptor and an IC50 of 100 nM for rat 5-lipoxygenase. CMI-392 blocks PAF receptor binding, inhibits leukotriene synthesis, attenuates PAF-induced hemoconcentration, and suppresses arachidonic acid- and TPA-induced ear swelling in mice. CMI-392 reduces inflammatory cell infiltration, decreases MPO levels, alleviates ocular inflammation, and improves dextran sulfate sodium-induced colitis. CMI-392 can be used in the research of inflammatory and immune-related diseases such as colitis and atopic dermatitis.
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PB-22 7-Hydroxyisoquinoline isomer
0 ImagesCat. No.: HY-172052CAS No.: 2365471-61-8PB-22 7-Hydroxyisoquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
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(±)-Oresbiusin A
0 ImagesCat. No.: HY-N16389BCAS No.: 906738-33-8(±)-Oresbiusin A is a racemate of Oresbiusin A (HY-N16389). Oresbiusin A is a plant secondary metabolite. Oresbiusin A can be isolated from Origanum dictamnus L.. Oresbiusin A exhibits antibacterial activity against Gram-negative bacteria (such as Acinetobacter hemolyticus, Empedobacter brevis, and Pseudomonas aeruginosa), with an MIC value of 0.236 μg/mL against Acinetobacter hemolyticus.
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4ʹ-Chloro deschloroalprazolam
0 ImagesCat. No.: HY-169471CAS No.: 92262-72-14ʹ-Chloro deschloroalprazolam is a benzodiazepine compound and is a derivative of alprazolam.
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(Rac)-Pyrotinib (Standard)
0 ImagesCat. No.: HY-104065ARCAS No.: 1246089-97-3Synonyms: (Rac)-SHR-1258 (Standard)(Rac)-Pyrotinib (Standard) is the analytical standard of (Rac)-Pyrotinib (HY-104065A). This product is intended for research and analytical applications. (Rac)-Pyrotinib ((Rac)-SHR-1258) is the racemic form of Pyrotinib (HY-104065). Pyrotinib is a potent and selective dual EGFR/HER2 receptor inhibitor.
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(Rac)-[6]-Gingerol
![(Rac)-[6]-Gingerol](https://file.medchemexpress.com/product_pic/hy-100187.gif "Click to View (Rac)-[6]-Gingerol Product Detail")
0 ImagesCat. No.: HY-100187CAS No.: 39886-76-5Synonyms: (±)-[6]-Gingerol(Rac)-[6]-Gingerol is a natural product. (Rac)-[6]-Gingerol can be isolated from rhizomes of Z. officinale. (Rac)-[6]-Gingerol shows moderate anticancer activity against lung cancer, ovarian cancer, melanoma, and colon cancer.
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(Rac)-Clodinafop-propargyl
0 ImagesCat. No.: HY-W683412CAS No.: 105511-96-4(Rac)-Clodinafop-propargyl is the racemic form of Clodinafop-propargyl (HY-136380). Clodinafop-propargyl is an arylphenoxypropionic acid herbicide that can be used to control the emergence of annual grasses.
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R-(+)-Mono-desmethylsibutramine
0 ImagesCat. No.: HY-U00290CAS No.: 229639-54-7R-(+)-Mono-desmethylsibutramine is the R enantiomer of Mono-desmethylsibutramine.
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Implitapide Racemate
0 ImagesCat. No.: HY-U00329CAS No.: 177277-99-5Implitapide Racemate is the racemate of Implitapide (HY-106130). Implitapide Racemate can be used in studies on the stereochemistry of Implitapide and related compounds.
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Cipropride (S enantiomer)
0 ImagesCat. No.: HY-U00403CAS No.: 66183-70-8Cipropride (S enantiomer) is the S enantiomer of cipropride; cipropride is an antiemetic agent.
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Oiligodendrocyte differentiation promoter 1
0 ImagesCat. No.: HY-U00394CAS No.: 400760-25-0Oiligodendrocyte differentiation promoter 1 belongs to the oiligodendrocyte differentiation promoter.
