Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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(R)-Oresbiusin A
0 ImagesCat. No.: HY-N16389ACAS No.: 136749-45-6(R)-Oresbiusin A, the enantiomer of Oresbiusin A (HY-N16389), is a chemical component isolated from the roots of Salvia plebeia.
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(2R)-Monolaurin
0 Images(2R)-Monolaurin ((2R)-1-Monolaurin) ((2r)-2,3-Dihydroxypropyl Dodecanoate) is the R-enantiomer of Monolaurin (HY-121620). (2R)-Monolaurin is significantly up-regulated in the rectal contents of weaned yaks after the addition of traditional Chinese medicine compound.
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(E)-YIC-C8-434
0 ImagesCat. No.: HY-138198CAS No.: 214265-97-1(E)-YIC-C8-434 is the E double-bond configuration of YIC-C8-434. YIC-C8-434 is an orally active ACAT inhibitor with anti-hypercholesterolemic activity.
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(+)-Picumeterol
0 ImagesCat. No.: HY-124950ACAS No.: 139423-79-3Synonyms: (+)-GR114297A(+)-Picumeterol is a configurations of Picumeterol (HY-124950). Picumeterol is a potent and selective β2-adrenoceptor agonist with bronchodilator and anti-bronchoconstrictor effects.
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rac-TNT-i
0 ImagesCat. No.: HY-157469ASynonyms: rac-NPD3064rac-TNT-i (rac-NPD3064) is the racomer of TNT-i (HY-157469). TNT-i is an inhibitor targeting M-Sec. TNT-i reversibly inhibits the formation of tunnel nanotubes (TNT) induced by M-Sec. TNT-i can reduce the production of wild-type HIV-1 in macrophages and T cells expressing M-Sec. TNT-i has low cytotoxicity towards macrophages and T cells. TNT-i can be used in studies related to HIV-1 infection.
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5-Fluoro PB-22 6-hydroxyquinoline isomer
0 ImagesCat. No.: HY-172036CAS No.: 2365471-03-85-Fluoro PB-22 N-(3-fluoropentyl) isomer is a structural isomer of 5-Fluoro PB-22.
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cis-Vitamin K1
0 ImagesCat. No.: HY-N0684ACAS No.: 16033-41-3Synonyms: cis-Phylloquinone; cis-Phytomenadionecis-Vitamin K1 (cis-Phylloquinone; cis-Phytomenadione) is an isomer of Vitamin K1 (HY-N0684) that can be used for the synthesis of Vitamin K1 (HY-N0684).
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1,2,3,5-Tetramethylbenzene
0 ImagesCat. No.: HY-W342261CAS No.: 527-53-7Synonyms: Isodurene1,2,3,5-Tetramethylbenzene (Isodurene) is an aromatic hydrocarbon isomer of tetramethylbenzene. 1,2,3,5-Tetramethylbenzene serves as an important component of industrial organic solvents. 1,2,3,5-Tetramethylbenzene can be used in the organic synthesis of plastics and resins. 1,2,3,5-Tetramethylbenzene exhibits potential neurotoxicity, acute oral toxicity and mild skin irritation activity.
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(±) Anabasine hydrochloride
0 ImagesCat. No.: HY-W209279CAS No.: 352220-15-6(±) Anabasine hydrochloride is the racemic form of Anabasine (HY-B1532). (±) Anabasine hydrochloride stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine hydrochloride inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine hydrochloride is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities.
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Stearyl linolenate
0 ImagesCat. No.: HY-N16141CAS No.: 17673-60-8Stearyl linolenate is an isomer of Oleyl linoleate (HY-165769).
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cis-Miyabenol C
0 ImagesCat. No.: HY-129133CAS No.: 168037-22-7cis-Miyabenol C is an isomer of the resveratrol trimer Miyabenol C, which can be isolated from grape herbs. Miyabenol C is an inhibitor of β-amyloid (Aβ) and amyloid β precursor protein (APP) in Alzheimer's disease model mice, and inhibit β-secretase activity without changing the protein level of β-secretase BACE1.
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15(R)-Prostaglandin I2 sodium
0 ImagesCat. No.: HY-W747129Synonyms: 15(R)-PGI2 sodium15(R)-Prostaglandin I2 (15(R)-PGI2) sodium is a 15(R)-stereoisomer of Epoprostenol (Prostaglandin I2) sodium (HY-A0126A).
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cis-Cyclooctene-amine
0 ImagesCat. No.: HY-141176Bcis-Cyclooctene-amine is the cis isomer of TCO-amine (HY-141176). TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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(S)-Hydroxychloroquine sulfate
0 ImagesCat. No.: HY-145530CAS No.: 155204-09-4Synonyms: (S)-HCQ sulfate(S)-Hydroxychloroquine ((S)-HCQ) sulfate is an isomer of Hydroxychloroquine (HY-W031727). (S)-Hydroxychloroquine sulfate (2.5-20 mg/mL) reduces the rate of insulin degradation in liver homogenates isolated from non-diabetic and diabetic rats. Formulations containing Hydroxychloroquine have been used in the study of malaria, rheumatoid arthritis, and systemic lupus erythematosus.
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15(R),19(R)-Hydroxy prostaglandin E1
0 ImagesCat. No.: HY-172572CAS No.: 55123-67-6Synonyms: 15(R),19(R)-Hydroxy PGE115(R),19(R)-Hydroxy prostaglandin E1 is a dihydroxy metabolite/stereoisomer of Prostaglandin E1 (HY-B0131). 15(R),19(R)-Hydroxy prostaglandin E1 is found in the semen of some mammals, especially primates.
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cis-Cyclooctene-amine hydrochloride
0 ImagesCat. No.: HY-141176CPurity: 99.89%cis-Cyclooctene-amine hydrochloride is the cis isomer of TCO-amine hydrochloride (HY-141176A). TCO-amine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine hydrochloride is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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(R)-GSK-F1
0 ImagesCat. No.: HY-100603BCAS No.: 1384097-28-2
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(3S,5S)-Fluvastatin sodium
0 ImagesCat. No.: HY-Z5058ACAS No.: 194935-01-8(3S,5S)-Fluvastatin sodium is the isomer of Fluvastatin sodium (HY-14664A). Fluvastatin sodium is a first fully synthetic, competitive HMG-CoA reductase inhibitor.
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rel-Avibactam sodium
0 ImagesCat. No.: HY-14879DCAS No.: 396731-20-7Synonyms: rel-NXL-104; rel-AVE1330Arel-Avibactam sodium (rel-NXL-104) is an isomer of Avibactam (HY-14879). Avibactam is a β-lactamase inhibitor with an IC50 of 8 nM against TEM-1 β-lactamase and an IC50 of 80 nM against P99 β-lactamase. Avibactam exhibits no significant intrinsic antibacterial activity when used alone. Avibactam restores the activity of Ceftazidime (HY-B0593) against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Avibactam does not enhance the activity of Ceftazidime against Acinetobacter spp., Burkholderia spp., or most anaerobic Gram-negative bacilli. Avibactam is used in research related to Gram-negative bacterial infections.
