TCO-amine

Cat. No.: HY-141176: Data Sheet
SDS
Handling Instructions
FAQs
Technical Support

TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

For research use only. We do not sell to patients.

TCO-amine Chemical Structure

CAS No. : 1799962-26-7

Size	Price	Stock
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of TCO-amine:

cis-Cyclooctene-amine Get quote
cis-Cyclooctene-amine hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC₅₀ & Target

Alkyl-Chain

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

226.32

Formula

C₁₂H₂₂N₂O₂

CAS No.

1799962-26-7

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(NCCCN)OC1CC/C=C/CCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (441.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4185 mL	22.0926 mL	44.1852 mL
5 mM	0.8837 mL	4.4185 mL	8.8370 mL
10 mM	0.4419 mL	2.2093 mL	4.4185 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (268 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4185 mL	22.0926 mL	44.1852 mL	110.4631 mL
	5 mM	0.8837 mL	4.4185 mL	8.8370 mL	22.0926 mL
	10 mM	0.4419 mL	2.2093 mL	4.4185 mL	11.0463 mL
	15 mM	0.2946 mL	1.4728 mL	2.9457 mL	7.3642 mL
	20 mM	0.2209 mL	1.1046 mL	2.2093 mL	5.5232 mL
	25 mM	0.1767 mL	0.8837 mL	1.7674 mL	4.4185 mL
	30 mM	0.1473 mL	0.7364 mL	1.4728 mL	3.6821 mL
	40 mM	0.1105 mL	0.5523 mL	1.1046 mL	2.7616 mL
	50 mM	0.0884 mL	0.4419 mL	0.8837 mL	2.2093 mL
	60 mM	0.0736 mL	0.3682 mL	0.7364 mL	1.8411 mL
	80 mM	0.0552 mL	0.2762 mL	0.5523 mL	1.3808 mL
	100 mM	0.0442 mL	0.2209 mL	0.4419 mL	1.1046 mL

TCO-amine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-amine1799962-26-7PROTAC LinkersInhibitorinhibitorinhibit

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