EGFR
All Product Categories
-
EGFR Inhibitors
(582)
View all products
-
EGFR Agonist
(1)
View all products
-
EGFR Antagonist
(1)
View all products
-
EGFR Activators
(5)
View all products
-
EGFR Modulators
(6)
View all products
-
EGFR Chemicals
(3)
View all products
-
EGFR Inducers
(4)
View all products
-
EGFR Degraders
(22)
View all products
-
EGFR Controls
(6)
View all products
-
EGFR Substrate
(1)
View all products
-
EGFR Ligands
(13)
View all products
-
EGFR Related Products (752)
Related Products (752)
-
Tucatinib hemiethanolate (Standard)
0 ImagesSynonyms: Irbinitinib hemiethanolate (Standard); ARRY-380 hemiethanolate (Standard); ONT-380 hemiethanolate (Standard)Tucatinib (hemiethanolate) (Standard) is the analytical standard of Tucatinib (hemiethanolate). This product is intended for research and analytical applications. Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.
-
PF-6422899
0 ImagesCat. No.: HY-135727CAS No.: 1621002-23-0
-
O-Desmethyl gefitinib (Standard)
0 ImagesCat. No.: HY-100064RCAS No.: 847949-49-9O-Desmethyl gefitinib (Standard) is the analytical standard of O-Desmethyl gefitinib. This product is intended for research and analytical applications. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays.
-
Pyrotinib dimaleate (Standard)
0 ImagesSynonyms: SHR-1258 dimaleate (Standard)Pyrotinib dimaleate (Standard) is the analytical standard of Pyrotinib dimaleate. This product is intended for research and analytical applications. Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively.
-
Rociletinib (Standard)
0 ImagesSynonyms: CO-1686 (Standard); AVL-301 (Standard); CNX-419 (Standard)Rociletinib (Standard) is the analytical standard of Rociletinib. This product is intended for research and analytical applications. Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.
-
Si306
0 ImagesCat. No.: HY-164527CAS No.: 1640012-88-9Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM).
-
Osimertinib dimesylate (Standard)
0 ImagesSynonyms: AZD-9291 dimesylate (Standard); Mereletinib dimesylate (Standard)Osimertinib (dimesylate) (Standard) is the analytical standard of Osimertinib (dimesylate). This product is intended for research and analytical applications. Osimertinib dimesylate (AZD-9291 dimesylate) is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively.
-
Canertinib dihydrochloride (Standard)
0 ImagesSynonyms: CI-1033 dihydrochloride (Standard); PD-183805 dihydrochloride (Standard)Canertinib (dihydrochloride) (Standard) is the analytical standard of Canertinib (dihydrochloride). This product is intended for research and analytical applications. Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice.
-
HKI-357 dimaleate
0 ImagesCat. No.: HY-103443ACAS No.: 915942-25-5
-
(E/Z)-Afatinib (Standard)
0 ImagesSynonyms: (E/Z)-BIBW 2992 (Standard)(E/Z)-Afatinib (Standard) is the analytical standard of (E/Z)-Afatinib. This product is intended for research and analytical applications. (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells.
-
GI261520A
0 ImagesCat. No.: HY-178740CAS No.: 179248-64-7GI261520A is a egfr/erbb2 dual inhibitor. GI261520A inhibits PhoQ phosphorylation dose-dependently. GI261520A can downregulate the activity levels of PhoP/PhoQ. GI261520A inhibits pagC reporter expression levels with an IC50 of 3.2 μM. GI261520A inhibits PhoQc autokinase activtiy by 80%. GI261520A can permeate the eukaryotic plasmatic and vascular cell membranes and reach intravacuolar Salmonella to block intramacrophage proliferation.
-
Lapatinib ditosylate (Standard)
0 ImagesSynonyms: GW572016 ditosylate (Standard); GW2016 ditosylate (Standard)Lapatinib (ditosylate) (Standard) is the analytical standard of Lapatinib (ditosylate). This product is intended for research and analytical applications. Lapatinib ditosylate (GW572016 ditosylate) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.
-
Mobocertinib (Standard)
0 ImagesSynonyms: TAK-788 (Standard); AP32788 (Standard)Mobocertinib (Standard) is the analytical standard of Mobocertinib. This product is intended for research and analytical applications. Mobocertinib (TAK-788) is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib can be used in NSCLC research.
-
Neratinib-d6
0 ImagesCat. No.: HY-32721SCAS No.: 1259519-18-0Neratinib-d6 (HKI-272-d6) is the deuterium labeled Neratinib. Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.
-
NSC 104999
0 ImagesCat. No.: HY-180480CAS No.: 1118745-14-4NSC 104999 is a Grb7 SH2 domain binder with moderate affinity (Kd = 32.3 μM). NSC 104999 exhibits anticancer activity against breast cancer.
-
Dacomitinib (Standard)
0 ImagesSynonyms: PF-00299804 (Standard); PF-299804 (Standard)Dacomitinib (Standard) is the analytical standard of Dacomitinib. This product is intended for research and analytical applications. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
-
Canertinib (Standard)
0 ImagesSynonyms: CI-1033 (Standard); PD-183805 (Standard)Canertinib (Standard) is the analytical standard of Canertinib. This product is intended for research and analytical applications. Canertinib (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice.
