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EGFR Related Products (757)
Related Products (757)
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Lapatinib ditosylate monohydrate (Standard)
0 ImagesSynonyms: GW572016 ditosylate monohydrate (Standard); GW2016 ditosylate monohydrate (Standard)Lapatinib (ditosylate monohydrate) (Standard) is the analytical standard of Lapatinib (ditosylate monohydrate). This product is intended for research and analytical applications. Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.
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DDC4002
0 ImagesCat. No.: HY-180325CAS No.: 2375048-04-5
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SSO111 sodium
0 ImagesCat. No.: HY-158828SSO111 sodium, a 20mer fully modified antisense oligonucleotide, targets the oncogene?HER2. SSO111 sodium induces exon 15 skipping during splicing, leading to the generation of a novel mRNA transcript that excludes exon 15. SSO111 sodium downregulated HER2 mRNA, which resulted in the inhibition of proliferation and induction of apoptosis in HER2-overexpressing tumor cells.
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ADS103317
0 ImagesCat. No.: HY-111072CAS No.: 934474-97-2ADS103317 is an analog of Afatinib (HY-10261). ADS103317 weakly inhibits MCH-1R. Afatinib is an EGFR inhibitor. ADS103317 can be used in research related to non-small cell lung cancer.
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Tyrphostin 25 (Standard)
0 ImagesCat. No.: HY-101958RCAS No.: 118409-58-8Synonyms: AG82 (Standard); Tyrphostin A 25 (Standard); Tyrphostin AG 82 (Standard); RG-50875 (Standard)Tyrphostin 25 (Standard) (AG82 (Standard)) is the analytical standard of Tyrphostin 25 (HY-101958). This product is intended for research and analytical applications. Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM.
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(Z)-RG-13022
0 ImagesCat. No.: HY-117523CAS No.: 149286-90-8Synonyms: (Z)-Tyrphostin RG13022(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells.
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AG-1478 (Standard)
0 ImagesCat. No.: HY-13524RCAS No.: 153436-53-4Synonyms: Tyrphostin AG-1478 (Standard); NSC 693255 (Standard)
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Methyl 2,5-dihydroxycinnamate (Standard)
0 ImagesCat. No.: HY-101006RCAS No.: 63177-57-1Methyl 2,5-dihydroxycinnamate (Standard) is the analytical standard of Methyl 2,5-dihydroxycinnamate. This product is intended for research and analytical applications. Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity.
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(E/Z)-AG490 (Standard)
0 ImagesCat. No.: HY-107459RCAS No.: 134036-52-5Synonyms: (E/Z)-Tyrphostin AG490 (Standard); (E/Z)-Tyrphostin B42 (Standard)(E/Z)-AG490 (Standard) is the analytical standard of (E/Z)-AG490 (HY-107459). This product is intended for research and analytical applications. (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine Kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
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LY456236 (Standard)
0 ImagesCat. No.: HY-103566RCAS No.: 338736-46-2LY456236 (Standard) is the analytical standard of LY456236 (HY-103566). This product is intended for research and analytical applications. LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 has anticonvulsant effects and blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research.
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4-Methyl erlotinib (Standard)
0 ImagesCat. No.: HY-129510RCAS No.: 1346601-52-24-Methyl erlotinib (Standard) is the analytical standard of 4-Methyl erlotinib. This product is intended for research and analytical applications. 4-Methyl erlotinib, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. 4-Methyl erlotinib potently inhibits EGF-mediated tumor cell mitosis by reducing EGFr-specific tyrosine phosphorylation. Using a mouse model of human tumor transplantation, 4-Methyl erlotinib demonstrated significant and sustained suppression of EGFr phosphotyrosine levels, resulting in significant growth inhibition of EGFr-dependent human cancers.
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Paeciloquinone E
0 ImagesCat. No.: HY-N14639CAS No.: 162797-36-6Paeciloquinone E can inhibit the EGFR protein tyrosine kinase.
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Mobocertinib succinate (Standard)
0 ImagesSynonyms: TAK-788 succinate (Standard); AP32788 succinate (Standard)Mobocertinib (succinate) (Standard) is the analytical standard of Mobocertinib (succinate). This product is intended for research and analytical applications. Mobocertinib (TAK-788) succinate is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib succinate potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib succinate can be used in NSCLC research.
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EAI001 (Standard)
0 ImagesCat. No.: HY-100214RCAS No.: 892772-75-7EAI001 (Standard) is the analytical standard of EAI001 (HY-100214). This product is intended for research and analytical applications. EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer.
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Varlitinib (Standard)
0 ImagesCat. No.: HY-10530RCAS No.: 845272-21-1Synonyms: ASLAN001 (Standard); ARRY-334543 (Standard)Varlitinib (Standard) is the analytical standard of Varlitinib (HY-10530). This product is intended for research and analytical applications. Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.
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Pelitinib-d6
0 ImagesCat. No.: HY-32718SCAS No.: 1325223-34-4
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2-2(t) aptamer sodium
0 ImagesCat. No.: HY-160068Purity: 99.28%2-2(t) aptamer sodium is a 42-nucleotide trimeric complex of aptamer (2-2) targeting ErbB-2. 2-2(t) aptamer sodium inhibits the growth of gastric cancer cells in vitro and in vivo.
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Lazertinib (Standard)
0 ImagesCat. No.: HY-109061RCAS No.: 1903008-80-9Synonyms: YH25448 (Standard); GNS-1480 (Standard)Lazertinib (Standard) is the analytical standard of Lazertinib (HY-109061). This product is intended for research and analytical applications. Lazertinib (YH25448) is a potent, selective, CNS-penetrant, orally available and irreversible EGFR tyrosine Kinase inhibitor, exhibiting high selectivity for activating (EGFRm) and T790M resistance mutations. Lazertinib inhibits phosphorylation of EGFR, AKT and ERK, leading to apoptosis and suppression of tumor growth in mouse H1975-luc brain metastasis xenograft models. Lazertinib can be used in the study of non-small cell lung cancer.
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CUDC-101 (Standard)
0 ImagesCat. No.: HY-10223RCAS No.: 1012054-59-9CUDC-101 (Standard) is the analytical standard of CUDC-101 (HY-10223). This product is intended for research and analytical applications. CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
