EGFR
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EGFR Related Products (757)
Related Products (757)
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Paeciloquinone D
0 ImagesCat. No.: HY-N14638CAS No.: 162797-35-5Paeciloquinone D can inhibit the EGFR protein tyrosine kinase.
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BML-265
0 ImagesCat. No.: HY-169948CAS No.: 183321-62-2BML-265 is a potent EGFR tyrosine kinase inhibitor. BML-265 disrupts Golgi integrity and abolishes secretory protein transport of diverse cargos. BML-265 affects Golgi integrity and transport in human cells but not in rodent cells.
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Piperonylic acid (Standard)
0 ImagesSynonyms: 2H-1,3-benzodioxole-5-carboxylic acid (Standard)Piperonylic acid (Standard) is the analytical standard of Piperonylic acid. This product is intended for research and analytical applications. Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities.
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Tesevatinib (Standard)
0 ImagesCat. No.: HY-13314RCAS No.: 781613-23-8Synonyms: XL-647 (Standard); EXEL-7647 (Standard); KD-019 (Standard)Tesevatinib (Standard) is the analytical standard of Tesevatinib. This product is intended for research and analytical applications. Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR). Tesevatinib significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM). Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity.
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CZC-8004 (Standard)
0 ImagesCat. No.: HY-111138RCAS No.: 916603-07-1Synonyms: CZC-00008004 (Standard)CZC-8004 (Standard) is the analytical standard of CZC-8004 (HY-111138). This product is intended for research and analytical applications. CZC-8004 (CZC-00008004) is a pan-Kinase inhibitor. CZC-8004 has IC50 values of 650 and 437 nM for EGFR WT and VEGFR2 V916M, respectively. CZC-8004 can be used in the study of cancer.
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EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard)
0 ImagesCat. No.: HY-103440RCAS No.: 881001-19-0EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard) is the analytical standard of EGFR/ErbB-2/ErbB-4 inhibitor-3 (HY-103440). This product is intended for research and analytical applications. EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively. EGFR/ErbB-2/ErbB-4 inhibitor-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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AV-412 free base (Standard)
0 ImagesCat. No.: HY-10346ARCAS No.: 451492-95-8Synonyms: MP-412 free base (Standard)AV-412 free base (Standard) is the analytical standard of AV-412 free base (HY-10346A). This product is intended for research and analytical applications. AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
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EGFR-IN-149
0 ImagesCat. No.: HY-169570CAS No.: 401638-52-6EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor (IC50: 0.42 nM).
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Theliatinib (Standard)
0 ImagesCat. No.: HY-104066RCAS No.: 1353644-70-8Synonyms: Xiliertinib (Standard); HMPL-309 (Standard)Theliatinib (Standard) is the analytical standard of Theliatinib (HY-104066). This product is intended for research and analytical applications. Theliatinib (Xiliertinib) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Theliatinib has an IC50 of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases. Theliatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CGP52411 (Standard)
0 ImagesCat. No.: HY-103442RCAS No.: 145915-58-8Synonyms: DAPH (Standard)CGP52411 (Standard) is the analytical standard of CGP52411 (HY-103442). This product is intended for research and analytical applications. CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitive EGFR inhibitor with an IC50 of 0.3 μM. CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells, and dramatic inhibits and reverses the formation of β-amyloid (Aβ42) fibril aggregates associated with Alzheimer's disease.
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Epertinib hydrochloride (Standard)
0 ImagesCat. No.: HY-107367ARCAS No.: 2071195-74-7Synonyms: S-22611 hydrochloride (Standard)Epertinib hydrochloride (Standard) (S-22611 hydrochloride (Standard)) is the analytical standard of Epertinib (hydrochloride) (HY-107367A). This product is intended for research and analytical applications. Epertinib (S-22611) hydrochloride is a potent, orally active, reversible, and selective tyrosine Kinase inhibitor of EGFR, HER4 and HER2, with IC50s of 1.48 nM, 2.49 nM and 7.15 nM, respectively. Epertinib hydrochloride shows potent antitumor activity. Epertinib (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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EGFR-IN-107
0 ImagesCat. No.: HY-163396EGFR-IN-107 (compound 3r) is an orally active EGFR inhibitor with IC50 values of 0.4333 μM for EGFRWT and 0.0438 μM for EGFRL858R/T790M. EGFR-IN-107 has anti-proliferative activity and can inhibit the proliferation of H1975 cells and induce their apoptosis. EGFR-IN-107 can be used in cancer research.
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NSC 228155 (Standard)
0 ImagesCat. No.: HY-101084RCAS No.: 113104-25-9NSC 228155 (Standard) is the analytical standard of NSC 228155 (HY-101084). This product is intended for research and analytical applications. NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM.
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(E)-AG 99 (Standard)
0 ImagesCat. No.: HY-100962RCAS No.: 122520-85-8Synonyms: (E)-Tyrphostin 46 (Standard); (E)-Tyrphostin AG 99 (Standard)
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SSOe26 sodium scrambled negative control
0 ImagesCat. No.: HY-158829ASSOe26 sodium scrambled negative control is the sequence scrambled negative control of SSOe26 sodium.
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EGFR-IN-146
0 ImagesCat. No.: HY-169566CAS No.: 166039-38-9
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Icotinib Hydrochloride (Standard)
0 ImagesSynonyms: BPI-2009H (Standard)Icotinib (Hydrochloride) (Standard) is the analytical standard of Icotinib (Hydrochloride). This product is intended for research and analytical applications. Icotinib Hydrochloride (BPI-2009) is a potent and specific EGFR inhibitor with an IC50 of 5 nM; also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M and EGFRL861Q. Icotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Tucatinib (Standard)
0 ImagesSynonyms: Irbinitinib (Standard); ARRY-380 (Standard); ONT-380 (Standard)Tucatinib (Standard) is the analytical standard of Tucatinib. This product is intended for research and analytical applications. Tucatinib (Irbinitinib) is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.
