GHSR
Growth hormone secretagogue receptor; Ghrelin receptor
GHSR (Growth hormone secretagogue receptor) is a seven transmembrane G protein-coupled receptor with high expression in the anterior pituitary, pancreatic islets, thyroid gland, heart and various regions of the brain. Two types of GHS-R are accepted to be present, GHS-R1a and GHS-R1b.
Ghrelin is a gastric polypeptide displaying strong GH-releasing activity by activation of the GHS-R1a located in the hypothalamus-pituitary axis. GHS-R1a is a G-protein-coupled receptor that, upon the binding of ghrelin or synthetic peptidyl and non-peptidyl ghrelin-mimetic agents known as GHS, preferentially couples to Gq, ultimately leading to increased intracellular calcium content. Beside the potent GH-releasing action, ghrelin and GHS influence food intake, gut motility, sleep, memory and behavior, glucose and lipid metabolism, cardiovascular performances, cell proliferation, immunological responses and reproduction.
GHSR Isoform Specific Products
All Product Categories
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GHSR Related Products (78)
Related Products (78)
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Antibodies (3)
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GHSR Isoform Comparison
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Macimorelin
0 ImagesCat. No.: HY-14820CAS No.: 381231-18-1Synonyms: EP-1572; AEZS-130
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BMS-604992 dihydrochloride
0 ImagesCat. No.: HY-14495BCAS No.: 1469750-46-6Synonyms: EX-1314 dihydrochlorideBMS-604992 (EX-1314) dihydrochloride is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. BMS-604992 dihydrochloride demonstrates high-affinity binding (ki=2.3 nM) and potent functional activity (EC50=0.4 nM). BMS-604992 dihydrochloride can stimulate food intake in rodents.
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KARI 201
0 ImagesCat. No.: HY-171962CAS No.: 2376132-22-6KARI 201 is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 is a ghrelin receptor agonist. KARI 201 improves neuropathological features of Alzheimer's disease.
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BMS-317180
0 ImagesCat. No.: HY-119125CAS No.: 295337-71-2BMS-317180 is an orally active and potent growth hormone secretagogue receptor (GHS-R) agonist (EC50=7.9 nM). BMS-317180 stimulates endogenous growth hormone (GH) release. BMS-317180 is promising for research of age-related frailty, osteoporosis, and cancer cachexia.
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Capromorelin
0 ImagesCat. No.: HY-15242CAS No.: 193273-66-4Synonyms: CP 424391Capromorelin (CP 424391) is a pyrazolinone-piperidine dipeptide. Capromorelin is an orally active and potent growth hormone secretagogue (GHS) (hGHS-R1a Ki=7 nM, rat pituicyte EC50=3 nM).
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Tezusomant
0 ImagesCat. No.: HY-P10964CAS No.: 2802416-72-2Tezusomant is a growth hormone receptor antagonist. Tezusomant is promising for research on diseases caused by excessive growth hormone secretion, such as acromegaly.
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GHRF, ovine
0 ImagesCat. No.: HY-P3056CAS No.: 94948-82-0GHRF, ovine is a growth hormone-releasing factor. GHRF is a specific mediator for the effects of hypoglycemia upon the release of pituitary growth hormone (GH).
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Anamorelin (Standard)
0 ImagesSynonyms: RC-1291 (Standard); ONO-7643 (Standard)Anamorelin (Standard) (RC-1291 (Standard)) is the analytical standard of Anamorelin (HY-14734). This product is intended for research and analytical applications. Anamorelin (RC-1291) is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin can be used in the research of anorexia and cancer cachexia.
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L-692429 hydrochloride
0 ImagesCat. No.: HY-10957ACAS No.: 169188-19-6Synonyms: MK-0751 hydrochlorideL-692429 (MK-0751) hydrochloride is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 hydrochloride binds to G protein-coupled receptor with a Ki of 63 nM.
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GSK894281
0 ImagesCat. No.: HY-111232CAS No.: 874958-63-1GSK894281 is an orally active and highly potent ghrelin receptor full agonist with a pEC50 of <4.9 at the human motilin receptor. GSK894281 effectively enters the CNS. GSK894281 has the potential for constipation or to assist in emptying the colon prior to colonoscopy or colon surgery research.
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JMV 3002
0 ImagesCat. No.: HY-129207CAS No.: 925239-03-8Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg.
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L-692429 (Standard)
0 ImagesCat. No.: HY-10957RCAS No.: 145455-23-8Synonyms: MK-0751 (Standard)L-692429 (Standard) is the analytical standard of L-692429 (HY-10957). This product is intended for research and analytical applications. L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a Ki of 63 nM.
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GHSR-1a agonist-1
0 ImagesCat. No.: HY-173271CAS No.: 3060887-25-1GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a), with an EC50 of 0.49 nM. GHSR-1a agonist-1 can effectively stimulate the release of endogenous growth hormone by activating GHSR-1a. GHSR-1a agonist-1 administered orally at a dose as low as 0.1 mg/kg can increase the body weight and body length of 4-week-old rats. GHSR-1a agonist-1 can be used in the research field of growth and development retardation in children.
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JMV 3008
0 ImagesCat. No.: HY-129287CAS No.: 925239-09-4JMV 3008 is a GHS-R1a antagonist with an IC50 of 5.6 nM. JMV 3008 can be used in the research of diseases such as diabetes and obesity.
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Anamorelin Fumarate
0 ImagesCat. No.: HY-14734BCAS No.: 339539-92-3Synonyms: RC-1291 Fumarate; ONO-7643 FumarateAnamorelin (RC-1291) Fumarate is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin Fumarate can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin Fumarate can be used in the research of anorexia and cancer cachexia.
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Ghrelin receptor full agonist-3
0 ImagesCat. No.: HY-180210CAS No.: 2243167-93-1Ghrelin receptor full agonist-3 (Compound 22) is a selective, potent and orally active ghrelin receptor full agonist with an EC50 of 1.8 nM. Ghrelin receptor full agonist-3 can stimulate pulsatile secretion of growth hormone (GH), significantly increasing the frequency and duration of GH secretion, thereby inducing a sustained increase in insulin-like growth factor-1 (IGF-1) levels. Ghrelin receptor full agonist-3 can be used for the researches of cancer and chronic obstructive pulmonary disease.
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SM-130686
0 ImagesCat. No.: HY-116959CAS No.: 259667-25-9SM-130686 is an oxindole derivative and an active GH secretagogue (GHS). SM-130686 stimulates GH release with a Half-maximum stimulation of 6.3 nM. SM-130686 has an orally active.
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KwFwLL-NH2
0 ImagesCat. No.: HY-P10673CAS No.: 942266-38-8KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC50=45.6 nM).
