Glycosidase
Glycosidase
Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].
References:
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
All Product Categories
-
Glycosidase Inhibitors
(448)
View all products
-
Glycosidase Antagonist
(1)
View all products
-
Glycosidase Activators
(20)
View all products
-
Glycosidase Modulators
(8)
View all products
-
Glycosidase Chemical
(1)
View all products
-
Glycosidase Inducers
(2)
View all products
-
Glycosidase Degrader
(1)
View all products
-
Glycosidase Controls
(5)
View all products
-
Glycosidase Substrates
(23)
View all products
-
Glycosidase Ligands
(3)
View all products
-
Glycosidase Related Products (688)
Related Products (688)
-
Antibodies (3)
-
7β-Hydroxybufalin
0 ImagesCat. No.: HY-N6575CAS No.: 20143-97-97β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and acetylcholinesterase.
-
α-Homonojirimycin
0 ImagesCat. No.: HY-119593CAS No.: 119557-99-2Synonyms: Homonojirimycinα-Homonojirimycin is a potent α-glucosidase inhibitor.
-
β-Glucanase 2(thermostable)
0 ImagesCat. No.: HY-P2763Aβ-Glucanase 2(thermostable) is a glucosidase enzyme located in on the brush border of the small intestine that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose). β-Glucanase 2 (thermostable) is an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.
-
α-Glucosidase-IN-88
0 ImagesCat. No.: HY-172757α-Glucosidase-IN-88 (Compound 3K) is an orally active and potent α-glucosidase inhibitor with an IC50 value of 6.40 µM. α-Glucosidase-IN-88 inhibits carbohydrate hydrolysis by blocking the enzyme's ability to break down glycosidic bonds, thereby reducing postprandial blood glucose levels. α-Glucosidase-IN-88 is promising for research of type 2 diabetes mellitus (T2DM).
-
Cedryl acetate (Standard)
0 ImagesCedryl acetate (Standard) is the analytical standard of Cedryl acetate. This product is intended for research and analytical applications. Cedryl acetate is an orally active α-glucosidase inhibitor with an IC50 of 94 μM against yeast α-glucosidase. Cedryl acetate reduces high-fat diet-induced body weight gain, visceral fat pad weight, adipocyte hypertrophy, hepatic lipid accumulation, glucose intolerance, insulin resistance and gluconeogenesis. Cedryl acetate can be used in the research of obesity and obesity-related metabolic syndrome.
-
4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one
0 ImagesCat. No.: HY-N17439CAS No.: 1799427-52-34-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one is a naphthalene derivative and a weak α-glucosidase inhibitor. 4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one can be found in the leaves of Cyclocarya paliurus. 4-Ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one can be used for the research of diabetes.
-
α-Glucosidase-IN-104
0 ImagesCat. No.: HY-179511α-Glucosidase-IN-104 (Compound 9s) is an efficient inhibitor of α-glucosidase with an IC50 of 24.32 μM. α-Glucosidase-IN-104 has a weak inhibitory effect on α-amylase and avoids gastrointestinal side effects. α-Glucosidase-IN-104 can be used for research on type 2 diabetes.
-
5-C-heptyl-DNJ
0 ImagesCat. No.: HY-144124CAS No.: 2734265-63-35-heptyl-DNJ is a potent GAA agonist with a Ki of 0.0047 μM. 5-C-heptyl-DNJ increases GAA activities by chaperrone effects.
-
Gal-dMor-Gem
0 ImagesCat. No.: HY-182898CAS No.: 3051812-84-8Gal-dMor-Gem is a selective senescent cell scavenger, Apoptosis inducer, and a prodrug of Gemcitabine (HY-17026). Gal-dMor-Gem releases Gemcitabine upon activation by Esterases and β-gal. Gal-dMor-Gem reduces SA-β-gal, preferentially induces apoptosis in senescent cells, regulates apoptosis-related proteins, accumulates in senescent tissues, and ameliorates senescence-related organ phenotypes. Gal-dMor-Gem is applicable to research on chemotherapy-induced senescence.
-
β-Glucanase 1(thermostable)
0 ImagesCat. No.: HY-P2763Bβ-Glucanase 1(thermostable) is a glucosidase enzyme located in on the brush border of the small intestine that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose). β-Glucanase 1 (thermostable) is an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.
-
α-Amylase/α-Glucosidase-IN-25
0 ImagesCat. No.: HY-184383α-Amylase/α-Glucosidase-IN-25 is a α-Amylase inhibitor and a competitive α-Glucosidase inhibitor, with an IC50 of 10.89 μM against α-glucosidase and an IC50 of 20.62 μM against α-amylase. α-Amylase/α-Glucosidase-IN-25 limits carbohydrate digestion. α-Amylase/α-Glucosidase-IN-25 can be used in the research of type 2 diabetes.
-
α-Glucosidase-IN-16
0 ImagesCat. No.: HY-151138CAS No.: 1606142-34-0α-Glucosidase-IN-16 is a potent and orally active α-glucosidase inhibitor with an IC50 value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin (HY-13753)-induced diabetic rats. Antidiabetic activity.
-
α-Glucosidase-IN-54
0 ImagesCat. No.: HY-N12664CAS No.: 174284-54-9α-Glucosidase-IN-54 (compound 2) is a α-glucosidase inhibitor with the IC50 of 0.011 mM, and can be isolated form Syzygium jambos (L.). α-Glucosidase-IN-54 can be used for study of diabetes.
-
OMJ-4
0 ImagesCat. No.: HY-181175CAS No.: 1531606-19-5OMJ-4 is a mutant alpha-mannosidase modulator. OMJ-4 can restore mutant alpha-mannosidase's catalytic function, and induces changes in compactness and active-site flexibility to improve substrate accommodation. OMJ-4 acts as an inducer of substrate reactivity, increasing the reactivity of mannose disaccharide bound to mutant alpha-mannosidase. OMJ-4 reduces the activation energy required for the enzymatic reaction of mutant alpha-mannosidase. OMJ-4 can be used for the research of alpha-mannosidosis.
-
α-Glucosidase-IN-29
0 ImagesCat. No.: HY-149342CAS No.: 2949513-11-3α-Glucosidase-IN-29 (compound 19) is a α-glucosidases inhibitor (IC50=1.21 μM, Ki=1.80 μM). α-Glucosidase-IN-29 ca be used for research of diabetes and related diseases.
