Glycosidase

Related Products

Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases^[1]^[2].

References:

[1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.

[2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]

Glycosidase Related Products (605)
Antibodies (3)

By Effects:	Inhibitors (419) Degraders (2) Controls (4) Substrates (18) Ligands (3) Antagonist (1) Activators (18) Modulators (7) Chemical (1) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-E70118

oligo-α-1,6-Glucosidase, Bacillus cereus ATCC7064
oligo-α-1,6-Glucosidase, Bacillus cereus ATCC7064 is a hydrolase that mainly hydrolyzes oligosaccharides with α-1,6-glycosidic bonds. oligo-α-1,6-Glucosidase, Bacillus cereus ATCC7064 can catalyzes the exo hydrolysis of α-1,6-glucoside bonds from the nonreducing ends of panose, palatinose, α-limit dextrins, and isomaltooligosaccharides. oligo-α-1,6-Glucosidase, Bacillus cereus ATCC7064 participates in the degradation pathway of starch and glycogen, assisting enzymes such as α-amylase to completely hydrolyzes amylopectin.

HY-N7170

(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid	Inhibitor
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is a α-Glucosidase inhibitor with an IC₅₀ value of 577.7 µM.

HY-N13813

Ethyl-3,5-di-O-caffeoylquinate	Control
Ethyl-3,5-di-O-caffeoylquinate is an ethyl caffeoylquinate (ECQ), and ECQ analogs are potential α-glucosidase (α-glucosidase) inhibitors and PTP1B inhibitors. Ethyl-3,5-di-O-caffeoylquinate, which can be isolated from the flower buds of Lonicera macranthoides, is an isomer of chlorogenic acid (ethyl dicaffeoylquinate).

HY-N10076

Ganomycin I	Inhibitor
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects.

HY-155344

α-Glucosidase-IN-38	Inhibitor
α-Glucosidase-IN-38 (Compound 11j) is a potent inhibitor of α-glucosidase inhibitor with IC₅₀ of 12.44±0.38 μM.α-Glucosidase-IN-38 plays an important role in Diabetes mellitus (DM).

HY-N11512

α-Glucosidase-IN-24	Inhibitor
α-Glucosidase-IN-24 (Compound 13) is an α-Glucosidase inhibitor with an IC₅₀ of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis.

HY-149533

α-Glucosidase-IN-34	Inhibitor
α-Glucosidase-IN-34 (compound 7f) is a potent α-glucosidase inhibitor (IC₅₀: 2.90 μM) and can be used in the study of type 2 diabetes and hyperglycemia.

HY-108903B

Hyaluronidase, Streptomyces hyalurolyticus
Hyaluronidase, Streptomyces hyalurolyticus (EC 3.2.1.35) degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. Hyaluronidase randomly cleaves β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.

HY-181476

α-Glucosidase-IN-113	Inhibitor
α-Glucosidase-IN-113 is an α-glucosidase inhibitor with an IC₅₀ of 17.52 μM. α-Glucosidase-IN-113 shows antiglycating activity and inhibits advanced glycation end-product formation. α-Glucosidase-IN-113 can be used for the research of type 2 diabetes.

HY-N11999

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl	Control
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase.

HY-154998

α-Glucosidase-IN-27	Inhibitor
α-Glucosidase-IN-27 (compound 8l) is an α-glucosidase inhibitor (IC₅₀=25.78 μM). α-Glucosidase-IN-27 has the potential to study type 2 diabetes (D2M).

HY-N17553

N-Formyldehydroanonaine	Inhibitor
N-Formyldehydroanonaine is a potent α-glucosidase inhibitor with an IC₅₀ of 104.6 μM against yeast α-glucosidase. N-Formyldehydroanonaine can be used for the research of diabetes mellitus.

HY-170797

α-Glucosidase-IN-80	Inhibitor
α-Glucosidase-IN-80 (Compound 10n) is a potent competitive inhibitor of α-glucosidase, with an IC₅₀ of 48.4 μM. α-Glucosidase-IN-80 has good pharmacokinetic properties and toxicity profiles and can be used in the research of diabetes-related diseases.

HY-178383

α-Glucosidase-IN-98	Inhibitor
α-Glucosidase-IN-98 is a potent orally active α-Glucosidase inhibitor with an IC₅₀ of 18.1 μM. α-Glucosidase-IN-98 reversibly binds with α-Glucosidase via hydrogen bonds, electrostatic interactions and hydrophobic effects, which induces significant conformational alterations in the secondary structure of α-Glucosidase. α-Glucosidase-IN-98 decreases postprandial hyperglycemia in Starch (HY-B2225B)/Sucrose (HY-B1779)-challenged mice. α-Glucosidase-IN-98 can be used for type 2 diabetes mellitus (T2DM) research.

HY-N19933

cis-3-O-Hydroxycinnamoyl-ursolic acid	Control
cis-3-O-Hydroxycinnamoyl-ursolic acid is a cis-cinnamic acid ester derivative. cis-3-O-Hydroxycinnamoyl-ursolic acid exhibits no α-glucosidase inhibitory activity.

HY-179141

α-Amylase/α-Glucosidase-IN-23	Inhibitor
α-Amylase/α-Glucosidase-IN-23 (Compound 5e) is a α-Amylase/α-Glucosidase inhibitor with IC₅₀ values of 73.68 nM for α-glucosidase and 146.18 nM for α-amylase. α-Amylase/α-Glucosidase-IN-23 can be used in the research of hypoglycemia.

HY-163439

α-Amylase/α-Glucosidase-IN-12	Inhibitor
α-Amylase/α-Glucosidase-IN-12 (compound 10k) is a dual inhibitor targeting α-glucosidase and α-amylase with IC₅₀ of 34.52 nM and 24.62 nM, respectively. α-Amylase/α-Glucosidase-IN-12 is an inhibitor designed based on triazolo[4,3-b][1,2,4]triazine and has the potential to be used in diabetes research.

HY-P2763

beta-Glucanase
beta-Glucanase belongs to glycosyl hydrolase family that hydrolyzes β-glucan polysaccharide, producing 3-O-cellotriosyl-d-glucose and 3-O-cellobiosyl-d-glucose. beta-Glucanase is capable of protecting plants against different fungal pathogens.

HY-182289

LY-23	Inhibitor
LY-23 is an orally active α-glucosidase inhibitor (K_i = 0.05 μM), with IC₅₀ values of 0.18 μM, 0.14 μM and 0.51 μM against maltase, sucrase and isomaltase, respectively. LY-23 reduces the level of postprandial blood glucose elevation. LY-23 is applicable to research related to postprandial hyperglycemia.

HY-172211

α-Amylase/α-Glucosidase-IN-17	Inhibitor
α-Amylase/α-Glucosidase-IN-17 (Compound 3) is an inhibitor of α-amylase and α-glucosidase, with IC₅₀ values of 14.61 μM and 25.38 μM, respectively. α-Amylase/α-Glucosidase-IN-17 has certain inhibitory activity against A549 cancer cells. α-Amylase/α-Glucosidase-IN-17 has anti-tumor and anti-diabetic effects.

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Glycosidase

Glycosidase

Glycosidase Related Products (605)

Antibodies (3)

Glycosidase Related Products (605):