HSP
Heat shock proteins
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.
HSP Isoform Specific Products
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HSP Inhibitors
(321)
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HSP Agonists
(2)
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HSP Antagonists
(5)
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HSP Activators
(84)
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HSP Modulators
(6)
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HSP Inducers
(6)
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HSP Degraders
(7)
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HSP Pre-designed Set
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HSP Controls
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HSP Ligands
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HSP Related Products (491)
Related Products (491)
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Antibodies (46)
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HSP Isoform Comparison
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ML229
0 ImagesCat. No.: HY-127183CAS No.: 898918-58-6ML229 is an HSP90 inhibitor. ML229 can be used in the research of infectious diseases such as candidiasis.
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BIIB-028
0 ImagesCat. No.: HY-12933CAS No.: 911398-13-5BIIB-028 is an orally active inhibitor for heat shock protein 90 (Hsp90). BIIB-028 targets the ATP-binding site of Hsp90, disrupts the function of Hsp90, leads to the degradation of client proteins, that are crucial for cancer cell survival and proliferation.
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Mequinol (Standard)
0 ImagesMequinol (Standard) is the analytical standard of Mequinol. This product is intended for research and analytical applications. Mequinol (4-Methoxyphenol)yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration. MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity.
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G3130
0 ImagesCat. No.: HY-111300CAS No.: 848952-37-4G3130 is a reversible HSP90 inhibitor with a Kd value of 280 nM for the N-terminal ATP-binding domain of purified human Hsp90α. G3130 binds to the adenine site via a multi-hydrogen bond network. G3130 induces the degradation of Hsp90 client protein Her-2 in breast cancer cells. G3130 activates Hsp70 promoter-driven luciferase expression in 293T cells. G3130 can be used in breast cancer-related research.
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Sudachitin
0 ImagesSudachitin is an orally active compound that potently inhibits mouse PDE1C and human PDE4B, with IC50 values of 5.0 μM and 15.0 μM, respectively. Sudachitin upregulates Sirt1 and PGC‑1α expression in skeletal muscle to regulate energy metabolism and promote mitochondrial biogenesis. Sudachitin improves lipid metabolism, glucose tolerance, insulin sensitivity, energy expenditure, and fatty acid β‑oxidation. Sudachitin activates p38MAPK signaling, induces HSP27 phosphorylation and caspase‑dependent apoptosis, and blocks EGF‑driven keratinocyte migration and proliferation. Sudachitin suppresses LPS‑induced TNF‑α, NO, and iNOS expression in macrophages and shows potent anti‑inflammatory activity. Sudachitin can be used for the research of metabolic syndrome, type 2 diabetes, and psoriasis..
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JG-48
0 ImagesCat. No.: HY-116279CAS No.: 1627122-26-2JG-48 is a Hsp70 inhibitor that can reduce tau levels in models of tauopathy.
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Retaspimycin
0 ImagesCat. No.: HY-15263CAS No.: 857402-23-4
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HSF1A (Standard)
0 ImagesCat. No.: HY-103000RCAS No.: 1196723-93-9HSF1A (Standard) is the analytical standard of HSF1A (HY-103000). This product is intended for research and analytical applications. HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding.
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VER-155008 (Standard)
0 ImagesCat. No.: HY-10941RCAS No.: 1134156-31-2VER-155008 (Standard) is the analytical standard of VER-155008 (HY-10941). This product is intended for research and analytical applications. VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
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Zelavespib (Standard)
0 ImagesCat. No.: HY-11038RCAS No.: 873436-91-0Synonyms: PU-H71 (Standard)Zelavespib (Standard) is the analytical standard of Zelavespib (HY-11038). This product is intended for research and analytical applications. Zelavespib (PU-H71) is a potent Hsp90 inhibitor, with an IC50 of 51 nM in MDA-MB-468 cells.
