1196723-93-9
1196723-93-9
Chemical Structure
HSF1A
- CAS No.: 1196723-93-9
- Formula:C21H19N3O2S2
- Molecular Weight:409.52
IUPAC Name: 4-ethyl-N-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl)benzenesulfonamide
InChIKey: KJTITGSAONQVPY-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(CC)C=C1)(NC2=CC(C3=CC=CS3)=NN2C4=CC=CC=C4)=O
Biological Activity: HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1)[1]. HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding[4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HSF1A | 99.94% | HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding. | ||||||||||||||||||||
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HSF1A (Standard) | ≥98% | HSF1A (Standard) is the analytical standard of HSF1A (HY-103000). This product is intended for research and analytical applications. HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding. | ||||||||||||||||||||
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References
- [1]. Neef DW, et al. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep. 2014 Nov 6;9(3):955-66. [Content Brief]
- [4]. Marcus Steinemann, et al. The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585. [Content Brief]
Keywords
