2. Signaling Pathways
  3. Anti-infection
  4. HSV

HSV

Herpes simplex virus

HSV

Related Products

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HSV (Herpes simplex virus) can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks. Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with ascab characteristic of herpetic disease. As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks.

HSV Isoform Specific Products:

HSV Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P11160
    GF-17
    		Inhibitor
    GF-17 is a polypeptide containing 17 amino acids. is the precursor peptide of GF19. GF-17 exhibits significant antiviral activity. GF-17 can be used for research on viral infections such as HSV-1 virus.
    GF-17
  • HY-N14564
    Cycloviracin B2
    		Inhibitor
    Cycloviracin B2 is an antibiotic with antiviral activity. Cycloviracin B2 has a strong inhibitory activity against herpes simplex virus type 1 (HSV-1).
    Cycloviracin B2
  • HY-B0180S1
    Imiquimod-d9
    		Inhibitor
    Imiquimod-d9 is deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19.
    Imiquimod-d<sub>9</sub>
  • HY-162701
    Antiviral agent 58
    		Inhibitor
    Antiviral agent 58 (Compound J1) is an orally active antiviral agent with broad-spectrum antiviral activity against enveloped viruses, including influenza A virus (IAV), respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human coronavirus OC43 (HCoV-OC43), herpes simplex virus type 1 (HSV-1), and HSV-2.
    Antiviral agent 58
  • HY-118745
    A-73209
    		Inhibitor
    A-73209 is an orally active and potent antivirus agent against VZV, HSV-1, and HSV-2. A-73209 is an Oxetanocin derivative and can be utilized in antivirus research.
    A-73209
  • HY-B1773AS2
    Sodium propionate-13C2
    		Inhibitor
    Sodium propionate-13C-2 is the 13C-labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.
    Sodium propionate-<sup>13</sup>C<sub>2</sub>
  • HY-B0180S
    Imiquimod-d6
    		Inhibitor
    Imiquimod-d6 is the deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19.
    Imiquimod-d<sub>6</sub>
  • HY-N2584AR
    Isoxanthohumol (Standard)
    		Inhibitor
    Isoxanthohumol (Standard) is the analytical standard of Isoxanthohumol (HY-N2584A). This product is intended for research and analytical applications. Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases.
    Isoxanthohumol (Standard)
  • HY-B0275BR
    Oxytetracycline dihydrate (Standard)
    		Inhibitor
    Oxytetracycline (dihydrate) (Standard) is the analytical standard of Oxytetracycline (dihydrate). This product is intended for research and analytical applications. Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity.
    Oxytetracycline dihydrate (Standard)
  • HY-15303AR
    Pritelivir mesylate (Standard)
    		Inhibitor
    Pritelivir (mesylate) (Standard) is the analytical standard of Pritelivir (mesylate). This product is intended for research and analytical applications. Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2.
    Pritelivir mesylate (Standard)
  • HY-N8041
    Mogroside III A2
    		Inhibitor
    Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1.
    Mogroside III A2
  • HY-15486R
    Salubrinal (Standard)
    		Inhibitor
    Salubrinal (Standard) is the analytical standard of Salubrinal. This product is intended for research and analytical applications. Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation. Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5.
    Salubrinal (Standard)
  • HY-106506R
    Desciclovir (Standard)
    		Control
    Desciclovir (Standard) is the analytical standard of Desciclovir. This product is intended for research and analytical applications. Desciclovir is a potent and orally active proagent of the antiherpetic agent Acyclovir (ACV). Desciclovir is converted to acyclovir in vivo by xanthine oxidase.
    Desciclovir (Standard)
  • HY-150306A
    (Rac)-Adibelivir
    		Inhibitor
    (Rac)-Adibelivir ((Rac)-IM-250) is a blood-brain barrier-penetrant HSV helicase-primase inhibitor and metabolic stabilizer with antiviral activity. (Rac)-Adibelivir is also effective against Acyclovir (HY-17422)-resistant strains, and its deuterated structure exhibits enhanced metabolic stability, reducing the formation of hydroxylated metabolites. (Rac)-Adibelivir prolongs in vivo half-life, reduces administration dosage, improves oral bioavailability, and achieves higher brain exposure in mice. (Rac)-Adibelivir can be used in the research of herpes simplex infection, herpes encephalitis and Alzheimer's disease.
    (Rac)-Adibelivir
  • HY-107009
    CTC 96
    		Inhibitor
    CTC 96 is an antiviral agent, showing inhibitory effects particularly on herpes viruses and adenoviruses. CTC 96 directly blocks the fusion process between the viral envelope and the cell membrane, preventing the entry of viral nucleic acids and proteins into the cells. CTC 96 can completely block the penetration and intercellular transmission of HSV-1, preventing the synthesis of viral proteins and mRNA. CTC 96 exhibits significant anti-adenovirus activity in rabbit eye models. CTC 96 is also effective against varicella-zoster virus (VZV) and vesicular stomatitis virus (VSV). CTC 96 can be used for broad-spectrum antiviral research.
    CTC 96
  • HY-B0420AR
    Moroxydine hydrochloride (Standard)
    		Inhibitor
    Moroxydine (ABOB) hydrochloride (Standard) is the analytical standard of Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels.
    Moroxydine hydrochloride (Standard)
  • HY-129983R
    5-Hydroxymethyl-2'-deoxyuridine (Standard)
    		Inhibitor
    5-Hydroxymethyl-2'-deoxyuridine (Standard) is the analytical standard of 5-Hydroxymethyl-2'-deoxyuridine. This product is intended for research and analytical applications. 5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia.
    5-Hydroxymethyl-2'-deoxyuridine (Standard)
  • HY-19187
    Acyclovir elaidate
    		Inhibitor
    Acyclovir elaidate (P-4010) is an orally active anti-HSV compound and Acyclovir (HY-17422) derivative. Acyclovir elaidate has the effect of ameliorating the symptoms of clinical disease in the experimental female guinea pig model of genital herpes.
    Acyclovir elaidate
  • HY-N14446
    Karalicin
    		Inhibitor
    Karalicin inhibits herpes simplex virus HSV-1, HSV-2, vaccinia virus, polio virus type I with the IC50s (μg/mL) of 0.004, 0.008, 0.016 and 0.016.
    Karalicin
  • HY-13966S3
    2-Deoxy-D-glucose-13C6
    		Inhibitor
    2-Deoxy-D-glucose-13C6 (2-DG-13C6) is 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
    2-Deoxy-D-glucose-<sup>13</sup>C<sub>6</sub>
HSV Isoform Comparison

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