Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
All Product Categories
-
Ligands for Target Protein for PROTAC Inhibitors
(3)
View all products
-
Ligands for Target Protein for PROTAC Chemicals
(6)
View all products
-
Ligands for Target Protein for PROTAC Degrader
(1)
View all products
-
Ligands for Target Protein for PROTAC Controls
(9)
View all products
-
Ligands for Target Protein for PROTAC Ligands
(14)
View all products
-
Ligands for Target Protein for PROTAC Related Products (683)
Related Products (683)
-
Related Compound Screening Libraries (1)
-
HG-7-85-01-NH2
0 ImagesHG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER.
-
Bestatin methyl ester
0 ImagesCat. No.: HY-137159CAS No.: 65322-89-6Bestatin methyl ester is a cell permeable Zn2+-binding aminopeptidases inhibitor. Bestatin methyl ester inhibits spore cell differentiation.
-
ER ligand-8
0 ImagesCat. No.: HY-201580CAS No.: 2229713-97-5ER ligand-8 is an ER (Estrogen Receptor/ERR) ligand that can be used to synthesize the PROTAC molecule ERD-1233 (HY-169367).
-
ET-JQ1-OH
0 ImagesCat. No.: HY-147046CAS No.: 2421153-77-5ET-JQ1-OH is an allele-specific BET inhibitor. ET-JQ1-OH can serve as a Ligand for Target Protein for PROTAC, and is used for the development and design of PROTAC Brd4 degraders, such as AB3145 (HY-180923).
-
BMS-1166-N-piperidine-COOH
0 ImagesCat. No.: HY-131187CAS No.: 2447066-00-2BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
-
OICR-9429-N-C2-NH2
0 ImagesCat. No.: HY-141798CAS No.: 2407457-55-8
-
UR241-2
0 ImagesUR241-2 is an IRAK4 inhibitor. UR241-2 suppresses IL-1–induced IRAK1/4 signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia.
