ET-JQ1-OH
ET-JQ1-OH is an allele-specific BET inhibitor. ET-JQ1-OH can serve as a Ligand for Target Protein for PROTAC, and is used for the development and design of PROTAC Brd4 degraders, such as AB3145 (HY-180923).
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- CAS. Nr.: 2421153-77-5
- Formel: C21H21ClN4O2S
- Molecular Weight:428.94
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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BRD4 |
In Vitro
ET-JQ1-OH (0.65 M; 1 week) is yielded as enantiopure product with 99% ee via treatment of ET-JQ1-OMe with lithium hydroxide in 4:1 THF:water at 45 °C for 1 week[1].
ET-JQ1-OH is successfully converted to its acid chloride derivative and conjugated to a heterotrivalent precursor to form the potent BromoTag PROTAC AB3145 (97)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2421153-77-5
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Molecular Weight 428.94
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Formel C21H21ClN4O2S
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SMILES
CC(C(C(C(C=C1)=CC=C1Cl)=N[C@@]2([H])[C@@H](CC)C(O)=O)=C(S3)N4C2=NN=C4C)=C3C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Bond AG, et al. Stereoselective synthesis of allele-specific BET inhibitors. Org Biomol Chem. 2020;18(38):7533-7539. [Content Brief]
[2]. Bond AG, et al. Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera. J Am Chem Soc. 2024;146(49):33675-33711. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ET-JQ1-OH Related Classifications
HY-147046 Related Classifications
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