ET-JQ1-OH
ET-JQ1-OH is an allele-specific BET inhibitor. ET-JQ1-OH can serve as a Ligand for Target Protein for PROTAC, and is used for the development and design of PROTAC Brd4 degraders, such as AB3145 (HY-180923).
For research use only. We do not sell to patients.
- CAS No.: 2421153-77-5
- Formula: C21H21ClN4O2S
- Molecular Weight:428.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRD4 |
ET-JQ1-OH (0.65 M; 1 week) is yielded as enantiopure product with 99% ee via treatment of ET-JQ1-OMe with lithium hydroxide in 4:1 THF:water at 45 °C for 1 week[1].
ET-JQ1-OH is successfully converted to its acid chloride derivative and conjugated to a heterotrivalent precursor to form the potent BromoTag PROTAC AB3145 (97)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2421153-77-5
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Molecular Weight 428.94
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Formula C21H21ClN4O2S
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SMILES
CC(C(C(C(C=C1)=CC=C1Cl)=N[C@@]2([H])[C@@H](CC)C(O)=O)=C(S3)N4C2=NN=C4C)=C3C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Bond AG, et al. Stereoselective synthesis of allele-specific BET inhibitors. Org Biomol Chem. 2020;18(38):7533-7539. [Content Brief]
[2]. Bond AG, et al. Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera. J Am Chem Soc. 2024;146(49):33675-33711. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ET-JQ1-OH Related Classifications
HY-147046 Related Classifications
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