2. Epigenetics PROTAC
  3. Epigenetic Reader Domain Ligands for Target Protein for PROTAC
  4. ET-JQ1-OH

ET-JQ1-OH is an allele-specific BET inhibitor. ET-JQ1-OH can serve as a Ligand for Target Protein for PROTAC, and is used for the development and design of PROTAC Brd4 degraders, such as AB3145 (HY-180923).

For research use only. We do not sell to patients.

ET-JQ1-OH

ET-JQ1-OH Chemical Structure

CAS No. : 2421153-77-5

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5 mg Get quote 4 - 6 weeks 3 - 5 weeks 5 - 7 weeks 3 - 5 weeks
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Based on 1 publication(s) in Google Scholar

ET-JQ1-OH Related Antibodies

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Description

ET-JQ1-OH is an allele-specific BET inhibitor. ET-JQ1-OH can serve as a Ligand for Target Protein for PROTAC, and is used for the development and design of PROTAC Brd4 degraders, such as AB3145 (HY-180923).

IC50 & Target

BRD4

 

In Vitro

ET-JQ1-OH (0.65 M; 1 week) is yielded as enantiopure product with 99% ee via treatment of ET-JQ1-OMe with lithium hydroxide in 4:1 THF:water at 45 °C for 1 week[1].
ET-JQ1-OH is successfully converted to its acid chloride derivative and conjugated to a heterotrivalent precursor to form the potent BromoTag PROTAC AB3145 (97)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ET-JQ1-OH Related Antibodies
Molecular Weight

428.94

Formula

C21H21ClN4O2S
CAS No.
SMILES

CC(C(C(C(C=C1)=CC=C1Cl)=N[C@@]2([H])[C@@H](CC)C(O)=O)=C(S3)N4C2=NN=C4C)=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ET-JQ1-OH Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ET-JQ1-OH2421153-77-5Epigenetic Reader DomainLigands for Target Protein for PROTACTarget Protein-binding MoietyBRD2Leu-Val mutant BET bromodomainsCRBNBRD3BromoTag-BRD4BET bromodomainstau-protein related diseaseLeu-Ala mutant BET bromodomainsInhibitorinhibitorinhibit

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Product Name:
ET-JQ1-OH
Cat. No.:
HY-147046
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