Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
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Ligands for Target Protein for PROTAC Chemicals
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Ligands for Target Protein for PROTAC Degrader
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Ligands for Target Protein for PROTAC Controls
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Ligands for Target Protein for PROTAC Ligands
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Ligands for Target Protein for PROTAC Related Products (682)
Related Products (682)
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Related Compound Screening Libraries (1)
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JH-VIII-49
0 ImagesCat. No.: HY-125001CAS No.: 2209084-73-9JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518).
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FAK ligand-2
0 ImagesCat. No.: HY-151010CAS No.: 2414478-49-0
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PROTAC BCR-ABL1 ligand 1
0 ImagesPROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1.
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SNX-5422 mesylate
0 ImagesCat. No.: HY-10213ACAS No.: 1173111-67-5Synonyms: PF-04929113 mesylateSNX-5422 Mesylate (PF-04929113 Mesylate), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37 nM.
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SirReal1-O-propargyl
0 ImagesCat. No.: HY-107453CAS No.: 1862237-99-7Synonyms: PROTAC Sirt2-binding moiety 1SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2. SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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BTA-1_b
0 ImagesCat. No.: HY-151035CAS No.: 95856-73-8Synonyms: BTA-1-CH3BTA-1_b (BTA-1-CH3) is a structural analog of BTA-1 (HY-W278021). BTA-1 is an uncharged derivative of Thioflavin-T. It exhibits high affinity for Aβ fibrils and demonstrates excellent brain penetration and clearance capabilities.
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EGFR ligand-15
0 ImagesCat. No.: HY-W109039CAS No.: 295330-45-9
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CPI-0610 carboxylic acid
0 ImagesCat. No.: HY-12863BCAS No.: 1380089-81-5CPI-0610 carboxylic acid is a ligand for target protein for PROTACT. CPI-0610 carboxylic acid is a potent bromodomain and extra-terminal (BET) protein inhibitor. CPI-0610 carboxylic acid has the potential in the therapy of multiple myeloma.
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A-1210477-piperazinyl
0 ImagesCat. No.: HY-125908CAS No.: 2351218-72-7Synonyms: PROTAC Mcl1-binding moiety 1A-1210477-piperazinyl is a compound binds to protein myeloid cell leukemia 1 (MCL1) used for PROTAC technology.
