Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
All Product Categories
-
Ligands for Target Protein for PROTAC Inhibitors
(3)
View all products
-
Ligands for Target Protein for PROTAC Chemicals
(6)
View all products
-
Ligands for Target Protein for PROTAC Degrader
(1)
View all products
-
Ligands for Target Protein for PROTAC Controls
(9)
View all products
-
Ligands for Target Protein for PROTAC Ligands
(12)
View all products
-
Ligands for Target Protein for PROTAC Related Products (686)
Related Products (686)
-
Related Compound Screening Libraries (1)
-
A-1210477-piperazinyl
0 ImagesCat. No.: HY-125908CAS No.: 2351218-72-7Synonyms: PROTAC Mcl1-binding moiety 1A-1210477-piperazinyl is a compound binds to protein myeloid cell leukemia 1 (MCL1) used for PROTAC technology.
-
Ipatasertib-NH2 dihydrochloride
0 ImagesCat. No.: HY-130988ACAS No.: 1001264-73-8Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride
-
AKT ligand-3
0 ImagesCat. No.: HY-184958CAS No.: 2376136-15-9
-
ALK ligand-2
0 ImagesCat. No.: HY-184540CAS No.: 2230198-74-8ALK ligand-2 (compound 3) is a ALK ligand that can be used to synthesize PROTAC degraders targeting ALK (HY-122582). ALK ligand-2 is applicable to research related to non-small cell lung cancer, anaplastic large cell lymphoma, and neuroblastoma.
-
N-Deshydroxyethyl Dasatinib-d8
0 ImagesCat. No.: HY-107447SCAS No.: 1189998-96-6
-
PXR Ligand 2
0 ImagesCat. No.: HY-169280CAS No.: 3059971-00-2
-
PDE4 ligand 2
0 ImagesCat. No.: HY-174410PDE4 ligand 2 is a CRBN E3 ligase ligand. PDE4 ligand 2 can be used to synthesize PROTAC such as PDE4 degrader-1 (HY-174405). PDE4 ligand 2 can be studied in research for autoimmune and anti-inflammatory diseases.
-
CDK2/4 ligand 1
0 ImagesCat. No.: HY-W1047040CAS No.: 1211585-07-7
-
2H-Indazole-7-carboxamide
0 ImagesCat. No.: HY-W973851CAS No.: 952479-70-82H-Indazole-7-carboxamide is a PARP1 ligand and can be used for the synthesis of PROTACs, such as PROTAC PARP1 degrader-1 (HY-158045).
