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Cat. No.: HY-187005

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HDAC8 ligand 2

HDAC8 ligand 2 is a HDAC8 ligand that can be used for the synthesis of PROTACs, such as SZUH280 (HY-152147).

For research use only. We do not sell to patients.

Formula: C₁₆H₁₄N₂O₃
Molecular Weight:282.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC8 ligand 2 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

HDAC8 ligand 2 is a HDAC8 ligand that can be used for the synthesis of PROTACs, such as SZUH280 (HY-152147)^[1].

IC₅₀ & Target^[1]

HDAC8

All HDAC Isoforms :

Chemical Information

Molecular Weight 282.29
Formula C₁₆H₁₄N₂O₃
SMILES

O=C(NO)C1=CC=C2C(N(CC3=CC=C(O)C=C3)C=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang J, et al. Structure-Based Discovery of Selective Histone Deacetylase 8 Degraders with Potent Anticancer Activity. J Med Chem. 2022 Dec 14. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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HDAC8 ligand 2

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HDAC8 ligand 2 Related Classifications

HY-187005 Related Classifications