Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
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Ligands for Target Protein for PROTAC Chemicals
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Ligands for Target Protein for PROTAC Degrader
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Ligands for Target Protein for PROTAC Controls
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Ligands for Target Protein for PROTAC Ligands
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Ligands for Target Protein for PROTAC Produits associés (686)
Produits associés (686)
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Related Compound Screening Libraries (1)
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CBP/p300 ligand 7
0 ImagesCat. No.: HY-175907CAS No.: 2832963-93-4CBP/p300 ligand 7 is a p300/CBP ligand that can be used for the synthesis of PROTACs, such as QC-182 (HY-162259).
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HSP70 ligand 1
0 ImagesCat. No.: HY-181148CAS No.: 952738-81-7HSP70 ligand 1, a HSP70 ligand, is a ligand for the target protein of PROTAC. HSP70 ligand 1 can be used to synthesize PROTAC HSP70 Degrader-1 (HY-181147).
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HDAC6 ligand-9
0 ImagesCat. No.: HY-184550CAS No.: 1206627-01-1HDAC6 ligand-9 (Compound 1a) is a ligands for target protein for PROTAC. HDAC6 ligand-9 can be used to synthesize PROTAC HDAC6 degrader-4 (HY-123971).
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TEAD ligand 1
0 ImagesCat. No.: HY-158400CAS No.: 2971850-47-0TEAD ligand 1 is the ligand for target protein TEAD. TEAD ligand 1 is utilized for synthesis of PROTAC TEAD degrader-1 (HY-158342).
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(Rac)-EBET-590
0 ImagesCat. No.: HY-161387ACAS No.: 3031540-02-7(Rac)-EBET-590 is the racemate of EBET-590 (HY-161387). (Rac)-EBET-590 is a BET ligand. (Rac)-EBET-590 can serve as a ligand for the target protein in the synthesis of PROTAC BET degraders, such as (Rac)-EBET-1055 (HY-161346A). (Rac)-EBET-590 is suitable for cancer research.
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PCSK9 ligand 2
0 ImagesCat. No.: HY-176044CAS No.: 3039841-82-9PCSK9 ligand 2 is a target protein ligand for PROTAC PCSK9 autophagic degrader 2 (HY-176043), which can be used in antiatherosclerosis research.
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Androgen receptor ligand 1
0 ImagesCat. No.: HY-172954CAS No.: 3077430-87-3Androgen receptor ligand 1 is an androgen receptor (AR) ligand. Androgen receptor ligand 1 binds to CRBN E3 ligase via a linker to form an AR PROTAC degrader. Androgen receptor ligand 1 can be used in the study of prostate cancer.
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BI-9321
0 ImagesCat. No.: HY-114208CAS No.: 2387510-86-1BI-9321, a chemical probe, is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.
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SMARCA2/SMARCA4 ligand-1
0 ImagesCat. No.: HY-182987SMARCA2/SMARCA4 ligand-1 is a SMARCA2/SMARCA4 ligand with KD values of 1.2 and 10.3 nM. SMARCA2/SMARCA4 ligand-1 binds SMARCA2/4 bromodomain via hydrogen bonds with asparagine and tyrosine residues, and a salt bridge with a glutamate residue. SMARCA2/SMARCA4 ligand-1 shows antiproliferative activity against cancer cells. SMARCA2/SMARCA4 ligand-1 can be used for the research of cancer, such as smarca4 mutant nonsmall cell lung cancer.
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TEAD ligand 4
0 ImagesCat. No.: HY-181592TEAD ligand 4 is a TEAD PROTAC ligand. TEAD ligand 4 can be conjugated with E3 ligase Ligand (HY-181591) and linker to synthesize PROTAC TEAD1/IAP degrader (HY-181590) .
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(Rac)-Spirotetramat-enol
0 ImagesCat. No.: HY-169009CAS No.: 382608-09-5(Rac)-Spirotetramat-enol is a ligand of acetyl-CoA carboxylase (ACC) that can be used for the synthesis of PROTAC ACC degrader-1 (HY-169008). (Rac)-Spirotetramat-enol binds to the carboxyltransferase domain and inhibits ACC activity in insects and spider mites. (Rac)-Spirotetramat-enol exhibits insecticidal activity against nymphs of the black bean aphid. (Rac)-Spirotetramat-enol can be used in studies related to black bean aphid infestation.
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GID4 Ligand 3
0 ImagesCat. No.: HY-151479CAS No.: 340007-39-8GID4 Ligand 3 (compound 16) is a binder of GID4 with an Kd value of 110 μM in vitro and an IC50 value of 148.5 μM. GID4 Ligand 3 can be used for the research related to cereblon and Von Hippel-Lindau.
