CDK2 degrader 2
Based on 1 Customer Validation
CDK2 degrader 2 (Compound I-10) is a PROTAC degrader for CDK2 that degrades CDK2 in MKN1 cell with a DC50 <100 nM.
(Pink: CDK2 ligand (HY-176124); Blue: Cereblon ligand (HY-45512); Black: linker (HY-W687952)).
For research use only. We do not sell to patients.
- Purity: 99.51%
- CAS No.: 3030271-16-7
- Formula: C46H57ClN10O6S
- Molecular Weight:913.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CDK2 degrader 2 selectively degrades CDK2 through the ubiquitin-proteasome pathway (UPP)[1].
Cyclin-dependent kinase (CDK) is a serine/threonine kinase that regulates cell cycle progression and cell division, followed by the heterodimerized with regulatory subunits known as cyclins, such as cyclin E1. Dysfunction of CDK2 leads to the proliferation inhibition of cancer cells, which can be used in anticancer researchs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3030271-16-7
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Appearance Solid
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Molecular Weight 913.53
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Formula C46H57ClN10O6S
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Color White to off-white
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SMILES
O=C1C(Cl)=CC2=C(N1C(C)C)N=C(NC3=CC=C(S(=O)(C4CCN(C5CCN(CC6CCN(CC6)C7=C(N(C)C(N8C9C(NC(CC9)=O)=O)=O)C8=CC=C7)CC5)CC4)=O)C=C3C)N=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (109.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0947 mL | 5.4733 mL | 10.9465 mL | 27.3664 mL |
| 5 mM | 0.2189 mL | 1.0947 mL | 2.1893 mL | 5.4733 mL | |
| 10 mM | 0.1095 mL | 0.5473 mL | 1.0947 mL | 2.7366 mL | |
| 15 mM | 0.0730 mL | 0.3649 mL | 0.7298 mL | 1.8244 mL | |
| 20 mM | 0.0547 mL | 0.2737 mL | 0.5473 mL | 1.3683 mL | |
| 25 mM | 0.0438 mL | 0.2189 mL | 0.4379 mL | 1.0947 mL | |
| 30 mM | 0.0365 mL | 0.1824 mL | 0.3649 mL | 0.9122 mL | |
| 40 mM | 0.0274 mL | 0.1368 mL | 0.2737 mL | 0.6842 mL | |
| 50 mM | 0.0219 mL | 0.1095 mL | 0.2189 mL | 0.5473 mL | |
| 60 mM | 0.0182 mL | 0.0912 mL | 0.1824 mL | 0.4561 mL | |
| 80 mM | 0.0137 mL | 0.0684 mL | 0.1368 mL | 0.3421 mL | |
| 100 mM | 0.0109 mL | 0.0547 mL | 0.1095 mL | 0.2737 mL |
CDK2 degrader 2 Related Classifications
HY-163815 Related Classifications
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