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Cat. No.: HY-176044

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PCSK9 ligand 2

PCSK9 ligand 2 is a target protein ligand for PROTAC PCSK9 autophagic degrader 2 (HY-176043), which can be used in antiatherosclerosis research.

For research use only. We do not sell to patients.

CAS No.: 3039841-82-9
Formula: C₁₆H₁₉N₃O₃S
Molecular Weight:333.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PCSK9 ligand 2 Chemical Structure

CAS No.: 3039841-82-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PCSK9 ligand 2 is a target protein ligand for PROTAC PCSK9 autophagic degrader 2 (HY-176043), which can be used in antiatherosclerosis research^[1].

Chemical Information

CAS No. 3039841-82-9
Molecular Weight 333.41
Formula C₁₆H₁₉N₃O₃S
SMILES

O=C(NC1=NC=CS1)CC2(C)NCCC3=C2C=C(O)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Autophagy
Autophagy is a process in which eukaryotic cells use lysosomes to degrade their own cytoplasmic proteins and damaged organelles under the regulation of autophagy related gene (Atg). Microtubule-associated proteins light chain 3 (LC3) is recognized as autophagy marker, which transfers from cytoplasmic LC3 (LC3-I) to membrane type (LC3-II). LC3-II/I ratio could be detected by Western Blot and fluorescence microscopy.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hongyu Wu, et al. PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation. J Med Chem. 2025 Apr 24;68(8):8190-8207. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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