YW-N-7 TFA

YW-N-7 (TFA) is a PROTAC that targets both the inhibition and degradation of RET kinase, with a DC₅₀ of 88 nM. YW-N-7 (TFA) exhibits antitumor activity in a KIF5B-RET-driven xenograft mouse tumor model and can be used in the area of cancer (Structure: red part represents the target protein ligand: HY-170856; blue part represents the E3 ligase ligand: HY-1708557; black part represents the linker; E3 ligase ligand + linker: HY-170858).
(Pink: RET ligand (HY-170856); Blue: E3 Ligase Ligand-Linker Conjugates ligand (HY-170858); Black: linker (HY-W086181)).

• Data Sheet (265 KB)