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Cat. No.: HY-184958

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AKT ligand-3

AKT ligand-3 is a Ligand for Target Protein for PROTAC that can be used in studies related to PROTAC synthesis. AKT ligand-3 serves as the target protein ligand for MS170 (HY-145282).

For research use only. We do not sell to patients.

CAS No.: 2376136-15-9
Formula: C₂₄H₃₀ClN₅O₄
Molecular Weight:487.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AKT ligand-3 Chemical Structure

CAS No.: 2376136-15-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AKT ligand-3 is a Ligand for Target Protein for PROTAC that can be used in studies related to PROTAC synthesis. AKT ligand-3 serves as the target protein ligand for MS170 (HY-145282)^[1].

IC₅₀ & Target^[1]

Akt

All Akt Isoforms :

In Vitro

AKT ligand-3 acts as a target protein ligand for MS170 (HY-145282). MS170 is a PROTAC AKT degrader with a DC₅₀ value of 32 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2376136-15-9
Molecular Weight 487.98
Formula C₂₄H₃₀ClN₅O₄
SMILES

OC(CCNC[C@H](C1=CC=C(C=C1)Cl)C(N2CCN(C3=C4C([C@@H](C[C@H]4C)O)=NC=N3)CC2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yu X, et al. Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders. Journal of medicinal chemistry. 2021 Dec 23;64(24):18054-18081. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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