1. PROTAC
    Autophagy
    Apoptosis
    Immunology/Inflammation
  2. Ligand for Target Protein for PROTAC
    FKBP
  3. SLF TFA

SLF TFA 

Cat. No.: HY-114872A Purity: 95.04% ee.: 100%
Handling Instructions

SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC.

For research use only. We do not sell to patients.

SLF TFA Chemical Structure

SLF TFA Chemical Structure

CAS No. : 2378802-47-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 105 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 105 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 75 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 560 In-stock
Estimated Time of Arrival: December 31
100 mg USD 930 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SLF TFA:

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Description

SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3].

In Vitro

Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

638.67

Formula

C₃₂H₄₁F₃N₂O₈

CAS No.
SMILES

OC(C(F)(F)F)=O.CCC(C)(C)C(C(N1[[email protected]@H](CCCC1)C(O[[email protected]@H](C2=CC(N)=CC=C2)CCC3=CC(OC)=C(C=C3)OC)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (313.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5658 mL 7.8288 mL 15.6575 mL
5 mM 0.3132 mL 1.5658 mL 3.1315 mL
10 mM 0.1566 mL 0.7829 mL 1.5658 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (7.83 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

SLFLigand for Target Protein for PROTACFKBPTarget Protein-binding MoietyFK506-binding proteinligandFKBP12FKBP51PROTACInhibitorinhibitorinhibit

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SLF TFA
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