Lipoxygenase
LOX
Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.
Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.
Lipoxygenase Isoform Specific Products
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Lipoxygenase Inhibitors
(277)
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Lipoxygenase Antagonists
(2)
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Lipoxygenase Activators
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Lipoxygenase Modulators
(3)
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Lipoxygenase Control
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Lipoxygenase Substrates
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Lipoxygenase Ligand
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Lipoxygenase Related Products (311)
Related Products (311)
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Antibodies (5)
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Lipoxygenase Isoform Comparison
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RBx-7796 sodium
0 ImagesCat. No.: HY-105711CAS No.: 794528-96-4RBx-7796 sodium is a competitive, highly selective, orally active 5-LO (IC50 = 3.5 mM for human 5-LO enzyme) inhibitor. RBx-7796 sodium can effectively inhibit 5-LO activity and LTB4 release. RBx-7796 sodium can significantly inhibit airway inflammation and bronchial constriction.
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ALOX5 stabilizer-1
0 ImagesCat. No.: HY-175634ALOX5 stabilizer-1 is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a Kd of 7.26 μM. ALOX5 stabilizer-1 inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 can used for the study of non-small cell lung cancer (NSCLC).
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LY269415
0 ImagesCat. No.: HY-120303CAS No.: 132392-65-5LY269415, is an anti-oxidant agent, is a potent and orally active iron dependent lipid peroxidation and 5-lipoxygenase enzyme inhibitor. LY269415 has anti-inflammatory effects.
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(1Z)-Atractylodinol
0 ImagesCat. No.: HY-N18235CAS No.: 362673-12-9(1Z)-Atractylodinol, an acetylenes compound, is a weak 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases.
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h15-LOX-2 inhibitor 1
0 ImagesCat. No.: HY-153930CAS No.: 478040-08-3h15-LOX-2 inhibitor 1 (Comp 105) is a human epithelial 15-lipoxygenase-2 (h15-LOX-2) inhibitor with IC50 of 0.34 μM.
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Setileuton tosylate
0 ImagesCat. No.: HY-10437ACAS No.: 1137737-87-1Synonyms: MK-0633 tosylateSetileuton tosylate is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively.
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FLM-5011
0 ImagesCat. No.: HY-106754CAS No.: 50652-76-1FLM-5011 is a lipoxygenase inhibitor. FLM-5011 can diminish myocardial ischaemia injury and shows anti-inflammatory effect. FLM-5011 can be used for the researches of inflammation and cardiovascular disease, such as myocarditis.
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CBS-1114 hydrochloride
0 ImagesCat. No.: HY-105983ACAS No.: 33244-00-7CBS-1114 hydrochloride is a potent 5-lipoxygenase inhibitor. CBS-1114 hydrochloride has the potential for inflammation and inflammation-related disorders research.
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Malotilate (Standard)
0 ImagesSynonyms: NKK 105 (Standard)Malotilate (Standard) is the analytical standard of Malotilate. This product is intended for research and analytical applications. Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes.
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S-(+)-Marmesin (Standard)
0 ImagesSynonyms: (+)-Marmesin (Standard); (S)-Marmesin (Standard)S-(+)-Marmesin (Standard) is the analytical standard of S-(+)-Marmesin. This product is intended for research and analytical applications. S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
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RG 6866
0 ImagesCat. No.: HY-118268CAS No.: 120602-97-3
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3-Aminobutanoic acid (Standard)
0 ImagesCat. No.: HY-W008833RCAS No.: 541-48-03-Aminobutanoic acid is a β-amino acid. 3-Aminobutanoic acid can protect plant against a challenge infection with P. infestans. 3-Aminobutanoic acid has various levels of susceptibility for the pathogen.
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Patulitrin
0 ImagesCat. No.: HY-N10020CAS No.: 19833-25-1Patulitrin has scavenging effect in the DPPH radical. Patulitrin inhibits soybean lipoxygenase. Patulitrin also has antihypertensive effect. Patulitrin is an antioxidant flavonoid that can be isolated from Anthemis tinctoria.
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h15-LOX-2 inhibitor 3
0 ImagesCat. No.: HY-161908CAS No.: 1164515-84-7h15-LOX-2 inhibitor 3 (Compound 13) is an inhibitor of h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.
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A-78773
0 ImagesCat. No.: HY-120606CAS No.: 141579-67-1A-78773 is a 5-lipoxygenase inhibitor. A-78773 can inhibit the formation of LTB4 in human whole blood and human neutrophils, with IC50 values of 85 nM and 20 nM, respectively. A-78773 can be used in the study of inflammation-related diseases.
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3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
0 ImagesCat. No.: HY-W319939CAS No.: 104236-73-93-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (Compound 5) is a selective lipid peroxidation inhibitor. 3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one is promising for research of diseases related to oxidative stress, such as cardiovascular diseases and neurodegenerative diseases.
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4-Nitrocatechol (Standard)
0 Images4-Nitrocatechol (Standard) is the analytical standard of 4-Nitrocatechol (HY-W066890). This product is intended for research and analytical applications. 4-Nitrocatechol is a Lipoxygenase inhibitor. 4-Nitrocatechol can serve as a ligand to stabilize the formation of metal complexes. As a (+) MALDI matrix, 4-Nitrocatechol significantly enhances the MALDI-MS detection and imaging of low-molecular-weight compounds in animal and plant tissue sections.
