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Cat. No.: HY-120606

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A-78773

A-78773 is a 5-lipoxygenase inhibitor. A-78773 can inhibit the formation of LTB₄ in human whole blood and human neutrophils, with IC₅₀ values of 85 nM and 20 nM, respectively. A-78773 can be used in the study of inflammation-related diseases.

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CAS No.: 141579-67-1
화학식: C₁₅H₁₃FN₂O₄
분자량:304.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

A-78773 Chemical Structure

CAS No.: 141579-67-1

사이즈

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Lipoxygenase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RBL-2H3	IC₅₀	298 nM Compound: A-78773	Inhibition of 5-lipoxygenase mediated conversion of [14C]arachidonic acid to leukotrienes in RBL-2H3 cells Inhibition of 5-lipoxygenase mediated conversion of [14C]arachidonic acid to leukotrienes in RBL-2H3 cells	[PMID: 9599246]

Chemical Information

CAS No. 141579-67-1
분자량 304.27
화학식 C₁₅H₁₃FN₂O₄
SMILES

O=C(N(O)C(C#CC1=CC=C(O1)OC2=CC=C(C=C2)F)C)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Basha A, et al. Second generation leukotriene biosynthesis inhibitors[J]. Pure and applied chemistry, 1994, 66(10-11): 2197-2200.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
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순도&문서
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A-78773

All Lipoxygenase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

A-78773 Related Classifications

HY-120606 Related Classifications