Monoamine Oxidase
MAO
Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.
Monoamine Oxidase Isoform Specific Products
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Monoamine Oxidase Inhibitors
(476)
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Monoamine Oxidase Activators
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Monoamine Oxidase Modulators
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Monoamine Oxidase Chemicals
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Monoamine Oxidase Substrate
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Monoamine Oxidase Ligands
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Monoamine Oxidase Related Products (511)
Related Products (511)
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Antibodies (2)
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Monoamine Oxidase Isoform Comparison
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7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
0 ImagesSynonyms: 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
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PF9601N
0 ImagesPF9601N, an monoamine oxidase B (MAO-B) inhibitor, possesses neuroprotective properties in several in vitro and in vivo models of Parkinson's disease (PD). PF9601N can be used for the research of neurodegenerative diseases mediated by excitotoxicity. PF9601N is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Pheniprazine
0 ImagesCat. No.: HY-W224327CAS No.: 55-52-7Synonyms: β-PhenylisopropylhydrazinePheniprazine is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression.
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MAO-B-IN-18
0 ImagesMAO-B-IN-18 is a potent and selective MAO B inhibitor with IC50s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures.
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Glicoricone
0 ImagesCat. No.: HY-N9329CAS No.: 161099-37-2Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC50 of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity.
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Gaultherin
0 ImagesGaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, COX-2 (IC50 = 0.35 mg/mL), LOX (IC50 = 0.56 mg/mL) and HYAL (IC50 = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654).
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Modaline sulfate
0 ImagesModaline sulfate is a MAO inhibitor, used in the treatment of depression.
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MAO-IN-1
0 ImagesMAO-IN-1 is a monoamine oxidase B (MAO B) inhibitor with an IC50 of 20 nM.
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Amitraz (Standard)
0 ImagesCat. No.: HY-B1111RCAS No.: 33089-61-1Synonyms: BTS-27419 (Standard)Amitraz (Standard) is the analytical standard of Amitraz. This product is intended for research and analytical applications. Amitraz is a non-systemic acaricide and insecticide with alpha-adrenergic agonist activity that interacts with octopamine receptors in the central nervous system and inhibits monoamine oxidase and prostaglandin synthesis.
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2-APB hydrochloride
0 Images2-APB is an analog of 6-APB, a benzofuran derivative and a psychoactive substance. Certain benzofuran derivatives have monoamine oxidase-A inhibitory activity .
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MAO-B-IN-64
0 ImagesCat. No.: HY-189245MAO-B-IN-64 is an orally active, blood-brain barrier-permeable reversible competitive inhibitor of monoamine oxidase B, with an IC50 of 0.35 nM against human MAO-B and a Ki of 0.22 nM for human MAO-B. MAO-B-IN-64 exhibits antioxidant effects by scavenging free radicals. MAO-B-IN-64 exerts anti-neuroinflammatory effects by inhibiting the release of pro-inflammatory factors. MAO-B-IN-64 acts as an H2S donor by releasing hydrogen sulfide. MAO-B-IN-64 can be applied in the research of Parkinson's disease.
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Lenumlostat hydrochloride
0 ImagesCat. No.: HY-107422ACAS No.: 2098884-53-6Synonyms: PAT-1251 hydrochloride; GB2064 hydrochloridePAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride is used in the research of fibrotic diseases.
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(S)-Rasagiline mesylate
0 ImagesCat. No.: HY-14200ACAS No.: 202464-88-8Synonyms: TVP1022 mesylate; S-PAI mesylate(S)-Rasagiline (TVP1022) mesylate is the relatively inactive S-enantiomer form of Rasagiline mesylate. Rasagiline mesylate is a highly potent selective irreversible MAO inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively.
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MAO A/HDAC-IN-1
0 ImagesCat. No.: HY-142706CAS No.: 3031466-56-2MAO A/HDAC-IN-1 is a dual?inhibitor?of monoamine oxidase A (MAO A) and HDAC. MAO A/HDAC-IN-1 can be used for glioma research. MAO A/HDAC-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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PXS-5505
0 ImagesSynonyms: LOX-IN-3 dihydrochloride monohydratePXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 can be used for fibrosis, cancer and angiogenesis research.
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RS 2232
0 ImagesCat. No.: HY-123129CAS No.: 85073-83-2RS 2232 is an orally active, competitive 5-HT deamination inhibitor with a Ki of 0.054 μM. RS-2232 exhibits reversible and specific inhibition of type A monoamine oxidase. RS 2232 can be used in brain research.
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hMAO-B-IN-7
0 ImagesCat. No.: HY-157400CAS No.: 2955577-14-5hMAO-B-IN-7 (compound 11n) is a potent and blood–brain barrier (BBB) penetrable inhibitor of human monoamine oxidase-B (hMAO-B), with the IC50 value of 0.79±0.05 μM. hMAO-B-IN-7 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research.
