Na+/K+ ATPase
Sodium potassium pump
Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.
The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.
All Product Categories
-
Na+/K+ ATPase Related Products (151)
Related Products (151)
-
Antibodies (11)
-
Chloroprocaine hydrochloride (Standard)
0 ImagesChloroprocaine (hydrochloride) (Standard) is the analytical standard of Chloroprocaine (hydrochloride). This product is intended for research and analytical applications. Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve.
-
S-WJM992
0 ImagesCat. No.: HY-159603S-WJM992 (compound 10ahb) is an antiparasitic agent that inhibits ATPase activity under high [Na+] conditions. S-WJM992 also has significant inhibitory effects on parasites that have developed PfATP4 inhibitor-resistance. S-WJM992 is a potential transmission blocker that effectively inhibits gamete development and prevents parasite transmission to mosquitoes via blood feeding.
-
(E)-3-(4-Methoxyphenyl)acrylic acid (Standard)
0 Images(E)-3-(4-Methoxyphenyl)acrylic acid (Standard) is the analytical standard of (E)-3-(4-Methoxyphenyl)acrylic acid (HY-W068771). This product is intended for research and analytical applications. (E)-3-(4-Methoxyphenyl)acrylic acid is an antioxidant and metal chelator that modulates E-NTPDase and Na+/K+ ATPase activities in iron-induced testicular injury by scavenging DPPH (HY-112053) free radicals, reducing ferric iron, chelating Fe2+, inhibiting lipid peroxidation, and enhancing GSH, SOD, and CAT activities. (E)-3-(4-Methoxyphenyl)acrylic acid can be used for research on iron-induced testicular injury.
-
Omeprazole-d3 sodium
0 ImagesCat. No.: HY-B0113S4Synonyms: H 16868-d3 sodiumOmeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole sodium (H 16868) is an orally active H+,K+-ATPase inhibitor and a proton pump inhibitor. Omeprazole sodium competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole sodium inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole sodium inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole sodium alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole sodium also has neuroprotective and antibacterial effects.
-
Oleic acid triethanolamine
0 ImagesSynonyms: 9-cis-Octadecenoic acid triethanolamine; 9Z-Octadecenoic acid triethanolamineOleic acid triethanolamine (9-cis-Octadecenoic acid triethanolamine) is the most common monounsaturated fatty acid found in human adipocytes and other tissues. Oleic acid triethanolamine is a Na+/K+ ATPase activator.
-
Rs-029
0 ImagesCat. No.: HY-120459CAS No.: 110230-95-0Rs-029 is an inhibitor Na+/K+ ATPase and an activator for Mg2+ ATPase. Rs-029 decreases the ATP level in red blood cells.
-
Carvacryl acetate
0 ImagesCarvacryl acetate is an orally active and brain-penetrant TRPA1 receptor activator and Na+/K+-ATPase activator. Carvacryl acetate modulates GABAergic signaling, alters hippocampal GABA and glutamine levels, reduces lipid peroxidation and nitrite formation, scavenges hydroxyl radicals, and boosts glutathione and antioxidant enzyme activity. Carvacryl acetate inhibits Haemonchus contortus larval hatching, development, adult motility, and fecal egg counts, and induces adult worm structural damage. Carvacryl acetate can be used for the research of intestinal mucositis, gastrointestinal nematode infection, epilepsy, and neurodegenerative diseases.
-
Azeloprazole
0 ImagesCat. No.: HY-109023CAS No.: 955095-45-1Azeloprazole is an orally active proton pump inhibitor. Azeloprazole irreversibly binds to and blocks the proton pump (H+/K+-ATPase) on parietal cells, thereby inhibiting gastric acid secretion. Azeloprazole is primarily metabolized by the CYP3A4 enzyme, and its pharmacokinetics and acid-suppressive effects are independent of CYP2C19 activity. Azeloprazole can be used for research on acid-related diseases such as reflux esophagitis and gastroesophageal reflux disease.
-
Ro18-5362
0 ImagesCat. No.: HY-U00193CAS No.: 101387-97-7Ro18-5362 is the less active proagent of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation.
