6380-28-5
Chemical Structure
Carvacryl acetate
- CAS No.: 6380-28-5
- Formula:C12H16O2
- Molecular Weight:192.25
IUPAC Name: 5-isopropyl-2-methylphenyl acetate
InChIKey: OXZSUQJHKQOGOK-UHFFFAOYSA-N
SMILES: O=C(C)OC1=CC(C(C)C)=CC=C1C
Biological Activity: Carvacryl acetate is an orally active and brain-penetrant TRPA1 receptor activator and Na+/K+-ATPase activator. Carvacryl acetate modulates GABAergic signaling, alters hippocampal GABA and glutamine levels, reduces lipid peroxidation and nitrite formation, scavenges hydroxyl radicals, and boosts glutathione and antioxidant enzyme activity. Carvacryl acetate inhibits Haemonchus contortus larval hatching, development, adult motility, and fecal egg counts, and induces adult worm structural damage. Carvacryl acetate can be used for the research of intestinal mucositis, gastrointestinal nematode infection, epilepsy, and neurodegenerative diseases[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Carvacryl acetate | 99.80% | Carvacryl acetate is an orally active and brain-penetrant TRPA1 receptor activator and Na+/K+-ATPase activator. Carvacryl acetate modulates GABAergic signaling, alters hippocampal GABA and glutamine levels, reduces lipid peroxidation and nitrite formation, scavenges hydroxyl radicals, and boosts glutathione and antioxidant enzyme activity. Carvacryl acetate inhibits Haemonchus contortus larval hatching, development, adult motility, and fecal egg counts, and induces adult worm structural damage. Carvacryl acetate can be used for the research of intestinal mucositis, gastrointestinal nematode infection, epilepsy, and neurodegenerative diseases. | ||||||||||||||||||||
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- [1]. Alvarenga EM, et al. Carvacryl acetate, a novel semisynthetic monoterpene ester, binds to the TRPA1 receptor and is effective in attenuating irinotecan-induced intestinal mucositis in mice. J Pharm Pharmacol. 2017;69(12):1773-1785. [Content Brief]
- [2]. Andre WP, et al. Comparative efficacy and toxic effects of carvacryl acetate and carvacrol on sheep gastrointestinal nematodes and mice. Vet Parasitol. 2016;218:52-58. [Content Brief]
- [3]. Pires LF, et al. Neuropharmacological effects of carvacryl acetate on δ-aminolevulinic dehydratase, Na+, K+-ATPase activities and amino acids levels in mice hippocampus after seizures. Chem Biol Interact. 2015;226:49-57. [Content Brief]
- [4]. Pires LF, et al. Is there a correlation between in vitro antioxidant potential and in vivo effect of carvacryl acetate against oxidative stress in mice hippocampus?. Neurochem Res. 2014;39(4):758-769. [Content Brief]
Keywords
