Neuropeptide Y Receptor
NPY receptor
Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.
Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).
Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.
Neuropeptide Y Receptor Isoform Specific Products
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Neuropeptide Y Receptor Inhibitors
(15)
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Neuropeptide Y Receptor Agonists
(71)
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Neuropeptide Y Receptor Antagonists
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Neuropeptide Y Receptor Activators
(2)
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Neuropeptide Y Receptor Modulators
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Neuropeptide Y Receptor Control
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Neuropeptide Y Receptor Related Products (181)
Related Products (181)
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Antibodies (8)
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Neuropeptide Y Receptor Isoform Comparison
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[D-Arg25]-Neuropeptide Y (human)
![[D-Arg25]-Neuropeptide Y (human)](https://file.medchemexpress.com/product_pic/hy-p0198b.gif "Click to View [D-Arg25]-Neuropeptide Y (human) Product Detail")
0 ImagesCat. No.: HY-P0198B[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y1 receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
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26Rfa, Hypothalamic Peptide, human
0 ImagesCat. No.: HY-P1915CAS No.: 600171-68-426Rfa, Hypothalamic Peptide, human is a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. 26RFa is an orexigenic neuropeptide identified as the endogenous ligand of the orphan G protein-coupled receptor GPR103.
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Neuropeptide AF (cattle)
0 ImagesCat. No.: HY-P3843CAS No.: 99588-52-0Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects.
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[Pro34]Neuropeptide Y, porcine
![[Pro34]Neuropeptide Y, porcine](https://file.medchemexpress.com/product_pic/hy-p10291.gif "Click to View [Pro34]Neuropeptide Y, porcine Product Detail")
0 ImagesCat. No.: HY-P10291CAS No.: 128768-54-7[Pro34]Neuropeptide Y, porcine is a selective NPY receptor (Y1 receptor) agonist. [Pro34]Neuropeptide Y, porcine evokes vasoconstrictions in the guinea pig caval vein.
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Y4R agonist-1
0 ImagesCat. No.: HY-P3359CAS No.: 2757328-51-9Y4R agonist-1 is a Y4R agonist with a Ki of 0.048 nM.
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Spexin TFA
0 ImagesCat. No.: HY-P1723ASynonyms: Neuropeptide Q TFASpexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy.
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NPY2R Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09516NPY2R Rat Pre-designed siRNA Set A contains three designed siRNAs for NPY2R gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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BWX 46
0 ImagesCat. No.: HY-P1325CAS No.: 172997-92-1Synonyms: ((Cys31, Nva 34)-Neuropeptide Y (27-36))2BWX 46 (((Cys31, Nva 34)-Neuropeptide Y (27-36))2) is a selective Y5 receptor agonist with an IC50 value of 0.85 nM. BWX 46 can inhibit the synthesis of cAMP in Y5 cells.
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(Pro34)-Peptide YY (human)
0 ImagesCat. No.: HY-P3876CAS No.: 179986-93-7(Pro34)-Peptide YY (human) is a highly Y1-selective full agonist of Peptide YY (HY-P1514)/neuropeptide Y receptors.
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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA
![[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA](https://file.medchemexpress.com/product_pic/hy-p1324a.gif "Click to View [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA Product Detail")
0 ImagesCat. No.: HY-P1324A[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.
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Neuropeptide Y Y1 receptor antagonist 1
0 ImagesCat. No.: HY-144603CAS No.: 2773476-40-5Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y1 receptor (Y1R), with a Ki of 0.19 nM.
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CGP71683
0 ImagesCat. No.: HY-107723ACAS No.: 192321-23-6CGP 71683 Free base serves as a powerful and highly selective non-peptide antagonist targeting the NPY Y(5) receptor, making it a valuable tool in obesity research.
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Neuropeptide Y (1-24) (human)
0 ImagesCat. No.: HY-P3679CAS No.: 131448-51-6Neuropeptide Y (1-24) (human) is a neuropeptide with potencies in inhibiting the electricity stimulated twitch response of rat vas deferens. Neuropeptide Y (1-24) (human) stimulates N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus in vivo.
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human GALP (3-32)
0 ImagesCat. No.: HY-P5894Synonyms: Galanin-like peptide (3-32)human GALP (3-32) (Galanin-like peptide (3-32)) is a potent galanin receptor agonist with high affinity for both GalR1 (IC50=33 nM) and GalR2 (IC50=15 nM) in a competitive binding study. human GALP (3-32) exhibits the high potency in altering the extracellular acidification rate of SH-SY5Y cells transfected with GalR2 (EC50=360 nM).
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Galanin-Like Peptide (rat)
0 ImagesCat. No.: HY-P5065CAS No.: 245114-97-0Galanin-Like Peptide (rat) is a 60 amino acid neuropeptide. Galanin-Like Peptide (rat) plays an important role in the regulation of feeding, body weight and energy metabolism.
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BIIE-0246 dihydrochloride
0 ImagesCat. No.: HY-101986CCAS No.: 246146-31-6Synonyms: AR-H 053591 dihydrochlorideBIIE-0246 dihydrochloride (AR-H 053591 dihydrochloride) is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist, with an IC50 value of 15 nM.
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TC4
0 ImagesCat. No.: HY-P11275TC4 is a highly balanced single-molecule quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.95, 31, 81, and 1100 nM respectively. TC4 exhibits extremely strong signal bias on GLP-1R and has very low recruitment efficacy for β-inhibitor protein 2 (βArr2) and this strong cAMP preference is believed to maximize metabolic benefits (such as weight loss and hypoglycemia) while possibly minimizing side effects mediated by β-inhibitor protein recruitment (such as receptor desensitization). TC4 can be used for research on obesity and diabetes.
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Peptide YY (pig)
0 ImagesCat. No.: HY-P2703CAS No.: 81858-94-8Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system.
