Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2436)
Related Products (2436)
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N1-Aminopseudouridine
0 ImagesCat. No.: HY-154109N1-Aminopseudouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-O-(tert-Butyldiphenylsilyl)-2,3-isopropylidene-D-ribonolactone
0 ImagesCat. No.: HY-154391CAS No.: 130222-84-35-O-(tert-Butyldiphenylsilyl)-2,3-isopropylidene-D-ribonolactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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8-Chloro-2’-beta-C-methyl inosine
0 ImagesCat. No.: HY-152508CAS No.: 1106012-39-88-Chloro-2’-beta-C-methyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Deoxy-2’-fluoro-N1-methyl inosine
0 ImagesCat. No.: HY-152492CAS No.: 2376610-64-72’-Deoxy-2’-fluoro-N1-methyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-O-(2-Methoxyethyl)-5-methyluridine
0 ImagesCat. No.: HY-154434CAS No.: 303197-29-73’-O-(2-Methoxyethyl)-5-methyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
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3-O-(4-Methoxybenzyl)-4-C-hydroxymethyl-1,2-O-isopropylidine-alpha-D-ribofuranose
0 ImagesCat. No.: HY-154503CAS No.: 225233-47-63-O-(4-Methoxybenzyl)-4-C-hydroxymethyl-1,2-O-isopropylidine-alpha-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine
![2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine](https://file.medchemexpress.com/product_pic/hy-154423.gif "Click to View 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine Product Detail")
0 ImagesCat. No.: HY-154423CAS No.: 177980-10-82′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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(S)-5-Amino-3-oxohexanoic acid
0 ImagesCat. No.: HY-180757CAS No.: 40802-96-8(S)-5-Amino-3-oxohexanoic acid is a nucleoside metabolite.
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BG-Nor
0 ImagesCat. No.: HY-D2957CAS No.: 3074567-08-8Synonyms: NorBG; SNAP-NorBG-Nor (NorBG) is a Benzylguanine analogue containing Norbornene (HY-W013021). BG-Nor can be converted by cell surface SNAP tags. NorBG can be used for tetrazine-linked labeling of cells via the iEDDA reaction.
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2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-methyluridine
0 ImagesCat. No.: HY-154071CAS No.: 2072145-23-22’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Thymine 1-β-D-arabinofuranoside
0 ImagesThymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-O-MOE-5Me-C(Bz)-2’-phosphoramidite
0 ImagesCat. No.: HY-154546CAS No.: 1098233-10-33’-O-MOE-5Me-C(Bz)-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-O-Benzoyl-1,2,3-tri-O-acetyl-4-C-methyl-D-ribofuranose
0 ImagesCat. No.: HY-154501CAS No.: 503543-44-05-O-Benzoyl-1,2,3-tri-O-acetyl-4-C-methyl-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N1-(1,1,1-Trifluoroethyl)pseudouridine
0 ImagesCat. No.: HY-152768CAS No.: 1613529-80-8N1-(1,1,1-Trifluoroethyl)pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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11,14,15-THETA
0 ImagesCat. No.: HY-180662CAS No.: 103488-86-4Synonyms: 11,14,15-Trihydroxyeicosatrienoic acid11,14,15-THETA (11,14,15-Trihydroxyeicosatrienoic acid) is a nucleoside metabolite.
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8-Methylthio-adenosine
0 ImagesCat. No.: HY-152511CAS No.: 29836-01-98-Methylthio-adenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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3’-beta-C-Ethynyl-3-deazauridine
0 ImagesCat. No.: HY-1524423’-beta-C-Ethynyl-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-beta-C-Ethynyl-3-deazauridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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1,2'-O-Dimethylguanosine
0 ImagesCat. No.: HY-137406CAS No.: 73667-71-71,2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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5’(R)-C-Methyl-3-deazauridine
0 ImagesCat. No.: HY-152651CAS No.: 2305415-82-95’(R)-C-Methyl-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Azido-3’-deoxy-5-iodouridine
0 ImagesCat. No.: HY-152724CAS No.: 2072145-33-43’-Azido-3’-deoxy-5-iodouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-5-iodouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
