Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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2’-Deoxy-2’-fluoro-β-D-arabino-2-thiouridine
0 ImagesCat. No.: HY-152349CAS No.: 1006872-85-02’-Deoxy-2’-fluoro-β-D-arabino-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Deoxy-2’-(N-trifluoroacetyl)amino-5’-O-DMTr-uridine 3’-CED phosphoramidite
0 ImagesCat. No.: HY-154525CAS No.: 126139-44-42’-Deoxy-2’-(N-trifluoroacetyl)amino-5’-O-DMTr-uridine 3’-CED phosphoramidite is a uridine analog.
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N3-(Butyn-3-yl)uridine
0 ImagesCat. No.: HY-154736N3-(Butyn-3-yl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents. N3-(Butyn-3-yl)uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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2’-β-C-Methyl-5-trifluoromethyluridine
0 ImagesCat. No.: HY-152745CAS No.: 2072145-39-02’-β-C-Methyl-5-trifluoromethyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Formylphosphonic acid
0 ImagesCat. No.: HY-180773CAS No.: 55217-41-9Formylphosphonic acid is a nucleoside metabolite.
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2’-Fluoro-2’-deoxy-N6,N6-dimethylarabinoadenosine
0 ImagesCat. No.: HY-152392CAS No.: 144924-81-22’-Fluoro-2’-deoxy-N6,N6-dimethylarabinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Benzylamino carbonyl-3’-O-acetyl-2’-O-methyluridine
0 ImagesCat. No.: HY-152879CAS No.: 2095417-64-25-Benzylamino carbonyl-3’-O-acetyl-2’-O-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
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N1-Methylxylo-guanosine
0 ImagesCat. No.: HY-152598N1-Methylxylo-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Deoxy-N2-cyclopentyl guanosine
0 ImagesCat. No.: HY-154430CAS No.: 1353757-90-02’-Deoxy-N2-cyclopentyl guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-O-Acetyl-N4-benzoyl-5’-O-DMT arabinocytidine 3’-O-phosphoramidite
0 ImagesCat. No.: HY-154207CAS No.: 675573-97-42’-O-Acetyl-N4-benzoyl-5’-O-DMT arabinocytidine 3’-O-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Amino-6-chloropurine-3’,5’-di-O-acetyl-2’-deoxyriboside
0 ImagesCat. No.: HY-154718CAS No.: 69992-11-62-Amino-6-chloropurine-3’,5’-di-O-acetyl-2’-deoxyriboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3-Methoxy-4-hydroxyphenylglycolaldehyde
0 ImagesCat. No.: HY-180704CAS No.: 17592-23-33-Methoxy-4-hydroxyphenylglycolaldehyde is a nucleoside metabolite.
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3’-O-(2-Azidoethyl)adenosine
0 ImagesCat. No.: HY-1528683’-O-(2-Azidoethyl)adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-O-(2-Azidoethyl)adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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5-Azidomethyl-2’,3’,5’-tri-O-benzoyl uridine
0 ImagesCat. No.: HY-154461CAS No.: 1884334-72-85-Azidomethyl-2’,3’,5’-tri-O-benzoyl uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 5-Azidomethyl-2’,3’,5’-tri-O-benzoyl uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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2′-β-C-Methyl-beta-D-6-methylpurine riboside
0 ImagesCat. No.: HY-152817CAS No.: 2095417-06-22′-β-C-Methyl-beta-D-6-methylpurine riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Deoxy-3’-fluoro-N6-methyladenosine
0 ImagesCat. No.: HY-152301CAS No.: 122654-27-73’-Deoxy-3’-fluoro-N6-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2',3'-O-Isopropylidene-5-pyrrolidinomethyl-2-thiouridine
0 ImagesCat. No.: HY-W564313CAS No.: 89845-82-92',3'-O-Isopropylidene-5-pyrrolidinomethyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
