Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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N6-Benzoyl-7'-O-DMT-morpholino adenine
0 ImagesCat. No.: HY-152984CAS No.: 2243974-77-6N6-Benzoyl-7'-O-DMT-morpholino adenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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5-Difluoromethyluridine
0 ImagesCat. No.: HY-152383CAS No.: 110483-84-65-Difluoromethyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-Deoxyadenosine monohydrate-1′-13C
0 ImagesCat. No.: HY-W011683SCAS No.: 446276-63-72'-Deoxyadenosine monohydrate-1′-13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
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1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4(1H)-pyrimidinone
0 ImagesCat. No.: HY-154325CAS No.: 37109-98-11-(2-Deoxy-β-D-erythro-pentofuranosyl)-4(1H)-pyrimidinone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5'-dAMPS
0 ImagesCat. No.: HY-131812CAS No.: 64145-26-2Synonyms: 2'-Deoxyadenosine 5'-O-thiophosphate5'-dAMPS is an analogue of 5'-dAMP and thus a potential substrate, competitive inhibitor or regulator of enzymes that interact with dAMP.
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N4-Amino-2’-β-C-methylcytidine
0 ImagesCat. No.: HY-152339CAS No.: 622381-10-6N4-Amino-2'-C-methylcytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Methyl 4-C-hydroxymethyl-2,3-O-isopropylidene-beta-D-ribofuranoside
0 ImagesCat. No.: HY-154499CAS No.: 55797-67-6Methyl 4-C-hydroxymethyl-2,3-O-isopropylidene-beta-D-ribofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N4-Benzoyl-3’-O-(2-methoxyethyl)-5-methylcytidine
0 ImagesCat. No.: HY-154449N4-Benzoyl-3’-O-(2-methoxyethyl)-5-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6-Ethyl-2’-C-methyladenosine
0 ImagesCat. No.: HY-152606CAS No.: 714250-18-7N6-Ethyl-2’-C-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N4-Benzoyl-2’-deoxy-2’,2’-diflurocytidine
0 ImagesCat. No.: HY-154220CAS No.: 142816-70-4N4-Benzoyl-2’-deoxy-2’,2’-diflurocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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4-Amino-1-(2-C-methyl-β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
![4-Amino-1-(2-C-methyl-β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile](https://file.medchemexpress.com/product_pic/hy-152718.gif "Click to View 4-Amino-1-(2-C-methyl-β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Product Detail")
0 ImagesCat. No.: HY-152718CAS No.: 847651-51-84-Amino-5-cyano-1-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2,6-Dichloro-2',3',5'-triacetyl-purine riboside
0 ImagesSynonyms: 2,6-Dichloro-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine2,6-Dichloro-2',3',5'-triacetyl-purine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Phanginin I
0 ImagesCat. No.: HY-N21628CAS No.: 1011528-66-7Phanginin I is a cassane-type furanoditerpene found in the seeds of Caesalpinia sappan. Phanginin I exhibits cytotoxicity against KB, HL-60, and HeLa cancer cells. Phanginin I can be used in research related to tumor cytotoxicity.
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DMT-dI Phosphoramidite
0 ImagesPhosphoramidite is a modified phosphoramidite monomer used for the oligonucleotide synthesis.
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2’-O-Methyl-5-methyl-4-thiouridine
0 ImagesCat. No.: HY-152518CAS No.: 2095417-26-62’-O-Methyl-5-methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N4-Desmethyl-N5-Methyl wyosine
0 ImagesCat. No.: HY-152797CAS No.: 59327-63-8N4-Desmethyl-N5-Methyl wyosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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3’-Azido-3’-deoxy-3-deazauridine
0 ImagesCat. No.: HY-154320CAS No.: 2305416-04-83’-Azido-3’-deoxy-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-3-deazauridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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8-Chloro-arabinoadenosine
0 ImagesCat. No.: HY-152387CAS No.: 769872-68-68-Chloro-arabinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
