P2X Receptor
P2XRs
P2X receptors are a family of seven (P2X1R-P2X7R) cation permeable ligand-gated ion channels (LGICs) that open in response to binding by the extracellular ligand, adenosine 5′-triphosphate (ATP). P2X receptors have a high permeability to Ca2+, Na+, and K+ and are expressed widely throughout the nervous, immune, cardiovascular, skeletal, gastrointestinal, respiratory, and endocrine systems.
P2X receptors are widely expressed in excitatory and non-excitatory cells, such as neuron, glia, platelet, epithelia and macrophage, and participate in many important physiological and pathological processes, including synaptic transmission, pain perception, inflammation, cardiovascular modulation, immunomodulation and tumorigenesis.
P2X Receptor Isoform Specific Products
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P2X Receptor Related Products (156)
Related Products (156)
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P2X Receptor Isoform Comparison
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Relicpixant
0 ImagesCat. No.: HY-159832CAS No.: 2445366-94-7Relicpixant is a potent purinoreceptor (P2X) antagonist.
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P2X4-IN-1
0 ImagesP2X4-IN-1 (Compound 1) is an orally active P2X4 inhibitor. P2X4-IN-1 can be used in the study of prophylaxis disease.
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P2X3 antagonist 37
0 ImagesCat. No.: HY-143576CAS No.: 2649318-40-9P2X3 antagonist 37 is a potent P2X3 receptor antagonist with an IC50 of 32.45 nM for hP2X3 (WO2021115225A1, example 68).
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Ro-51
0 ImagesCat. No.: HY-14485CAS No.: 1050670-85-3Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.
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P2X3 antagonist 36
0 ImagesCat. No.: HY-143568CAS No.: 2310263-59-1P2X3 antagonist 36 is a P2X3 antagonist extracted from patent WO2019081343A1 compound 156.
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8-Bromo-ATP
0 ImagesCat. No.: HY-134262CAS No.: 23567-97-7Synonyms: 8-Bromoadenosine 5'-triphosphate; 8-Br-ATP8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM.
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P2X7 receptor antagonist-5
0 ImagesCat. No.: HY-162951CAS No.: 3046388-16-0P2X7 receptor antagonist-5 (compund 13a) is a potent, orally active and long-lasting P2X7 receptor antagonist.
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Z1456467176
0 ImagesCat. No.: HY-184711CAS No.: 1606572-10-4Z1456467176 is an allosteric inhibitor of P2X7R. Z1456467176 binds to P2X7R, prevents ATP-induced channel opening and receptor activation, and blocks ATP-induced activation of the NLRP3-caspase-1-IL-1β pathway. Z1456467176 inhibits ATP-induced P2X7R pore formation in macrophages, as well as IL-1β secretion induced by ATP or BzATP. Z1456467176 alleviates gouty joint inflammation in rats. Z1456467176 can be used for the research of gouty arthritis.
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TNP-GTP tetrasodium
0 ImagesCat. No.: HY-137609ASynonyms: TNP-Guanosine 5'-triphosphate tetrasodiumTNP-GTP tetrasodium is a fluorescently labeled GTP (HY-113225) derivative. TNP-GTP tetrasodium can inhibit glutamate dehydrogenase (Ki = 2.7 μM). TNP-GTP tetrasodium is an antagonist of the purinergic P2X2 and P2X2/3 receptors with IC50 values of 0.4 and 1.2 nM, respectively. TNP-GTP tetrasodium also inhibit rat soluble guanylyl cyclase (Ki = 11 nM).
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P2X7 receptor antagonist-3
0 ImagesCat. No.: HY-148558CAS No.: 1627900-92-8P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats.
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Opiranserin
0 ImagesCat. No.: HY-109067CAS No.: 1441000-45-8Synonyms: VVZ-149Opiranserin (VVZ-149), a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin is development as an injectable agent for the treatment of postoperative pain.
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GSK1370319A
0 ImagesCat. No.: HY-165557CAS No.: 1001389-31-6GSK1370319A is a human P2X7 receptor inhibitor with an IC50 of 474 nM and a Ki of 176 nM. GSK1370319A inhibits the production of IL-1β, reduces the generation of reactive oxygen species (ROS), and increases the survival rate of macrophages. GSK1370319A can be used for the research of inflammatory bowel disease.
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P2X2/3-antagonist-1
0 ImagesCat. No.: HY-189007P2X2/3-antagonist-1 is a P2X2/3 purinergic receptor antagonist and taste blocker. P2X2/3-antagonist-1 binds to an allosteric site, induces a concentration-dependent rightward shift of the concentration-response curve of the α,β-Me-ATP agonist, and shares the binding site with AF-353 (HY-14483). P2X2/3-antagonist-1 blocks bitter taste perception in mice and abolishes their preference for plain water over bitter Quinine (HY-D0143) solution.
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MK-3901
0 ImagesCat. No.: HY-122163CAS No.: 1149750-69-5
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Eperisone
0 ImagesCat. No.: HY-128891CAS No.: 64840-90-0Eperisone ((±)-Eperisone) is an antispasmodic agent and centrally acting muscle relaxant useful in the study of diseases characterized by muscle stiffness and pain. Eperisone acts by relaxing skeletal and vascular smooth muscle, resulting in vasodilation, decreased muscle tone, improved circulation, and inhibition of pain reflexes. Eperisone is also a potent P2X7 receptor antagonist.
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P2X receptor-1
0 ImagesCat. No.: HY-139627CAS No.: 3051864-35-5P2X receptor-1 is a potential inhibitor of P2X receptor for the research of pain and inflammation.
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MRS 2219
0 ImagesCat. No.: HY-102063CAS No.: 14141-47-0Synonyms: Pyridoxol, cyclic 3,4-hydrogen phosphateMRS 2219 (Pyridoxol) is a selective pharmacological probe of P2X1 receptor. MRS 2219 selectively potentiated ATP-evoked responses at P2X1 receptors with an EC50 of 5.9 μM.
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α,β-Methylene-ATP
0 ImagesCat. No.: HY-134440ACAS No.: 7292-42-4α,β-Methylene-ATP is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system.
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Anti-P2XR4 Antibody
0 ImagesCat. No.: HY-P992286
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P2X2/3 modulator-1
0 ImagesCat. No.: HY-153548CAS No.: 1217483-98-1P2X2/3 modulator-1 (Compound 46) is a P2X2/3 modulator. P2X2/3 modulator-1 can be used in the study of pain, central nervous system disorders and inflammation.
