1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    GPCR/G Protein
  2. GlyT
    5-HT Receptor
    P2X Receptor
  3. Opiranserin

Opiranserin 

Cat. No.: HY-109067
Handling Instructions

Opiranserin, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin is development as an injectable agent for the treatment of postoperative pain.

For research use only. We do not sell to patients.

Opiranserin Chemical Structure

Opiranserin Chemical Structure

CAS No. : 1441000-45-8

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Description

Opiranserin, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin is development as an injectable agent for the treatment of postoperative pain[1][2][3].

IC50 & Target

5-HT2A Receptor

1.3 μM (IC50)

GlyT2

0.86 μM (IC50)

rP2X3

0.87 μM (IC50)

Molecular Weight

394.51

Formula

C₂₁H₃₄N₂O₅

CAS No.

1441000-45-8

SMILES

O=C(C1=CC(OC)=C(OCCCC)C(OC)=C1)NCC2(CCOCC2)N(C)C

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OpiranserinGlyT5-HT ReceptorP2X ReceptorGlycine transportersSerotonin Receptor5-hydroxytryptamine ReceptorP2XRspainanalgesicnon-opioidnon-non-steroidalanti-inflammatorypostoperativeInhibitorinhibitorinhibit

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