PKC
Protein Kinase C Alpha (PKCα) is a serine/threonine kinase involved in diverse cellular processes including proliferation, differentiation, and apoptosis. It plays a critical role in signal transduction pathways downstream of G-protein-coupled receptors and receptor tyrosine kinases[1]. PKCα regulates cell survival and growth through activation of the MAPK/ERK and PI3K/AKT pathways[2]. In cancer, PKCα is often overexpressed and contributes to tumor progression, particularly in breast and prostate cancers[3]. It also modulates vascular smooth muscle contraction and endothelial function, implicating it in cardiovascular diseases. Notably, PKCα exhibits distinct functions compared to other PKC isoforms due to its unique subcellular localization and substrate specificity[4]. Targeting PKCα with selective inhibitors such as Gö6976 has shown therapeutic potential in preclinical models of cancer and inflammatory disorders[5].
References:
- [1]. Lee MJ, et al. Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial. Lancet HIV. 2026 May 27:S2352-3018(26)00059-7. [Content Brief]
- [2]. Wolf S, et al. Selection for Evi1 activation in myelomonocytic leukemia induced by hyperactive signaling through wild-type NRas. Oncogene. 2013 Jun 20;32(25):3028-38. [Content Brief]
- [3]. Ali SR, et al. Nerve Density and Neuronal Biomarkers in Cancer. Cancers (Basel). 2022 Oct 1;14(19):4817. [Content Brief]
- [4]. Kim JY, et al. The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin-treated mice. Cell Signal. 2010 Nov;22(11):1669-80. [Content Brief]
- [5]. Ciglenecki I, et al. Low sensitivity of the fourth-generation antigen/antibody HIV rapid diagnostic test Determine™ HIV Early Detect for detection of acute HIV infection at the point of care in rural Eswatini: a diagnostic accuracy study. J Int AIDS Soc. 2025 Jul;28(7):e26517. [Content Brief]
All Product Categories
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PKC Related Products (383)
Related Products (383)
![[Ala113]MBP(104-118) TFA](https://file.medchemexpress.com/product_pic/hy-p1289c.gif "Click to View [Ala113]MBP(104-118) TFA Product Detail")
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MS-347a
0 ImagesCat. No.: HY-N19735CAS No.: 144678-18-2MS-347a is an inhibitor of myosin light chain kinase (MLCK) and protein kinase C (PKC), with IC50 values of 9.2 μM, 31 μM and 16 μM against calmodulin-dependent MLCK, calmodulin-independent MLCK and PKC, respectively. MS-347a binds to the catalytic domain of MLCK and blocks both calmodulin-dependent and calmodulin-independent MLCK activity. MS-347a inhibits the growth of drug-sensitive fission yeast and multiple ascomycete phytopathogenic fungi. MS-347a exhibits fungicidal activity against a variety of phytopathogenic fungi and protective activity against Magnaporthe oryzae in rice seedlings. MS-347a shows antibacterial activity against specific Gram-positive bacteria and Proteus vulgaris. MS-347a can be used in studies related to rice blast, bacterial infections and phytopathogenic fungal diseases.
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12-Deoxyphorbol-13-isobutyrate-20-acetate
0 ImagesCat. No.: HY-N18070CAS No.: 25090-71-512-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection.
![[Ala107]MBP(104-118) TFA](https://file.medchemexpress.com/product_pic/hy-p1289b.gif "Click to View [Ala107]MBP(104-118) TFA Product Detail")
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PKCθ Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70856PKCθ is a member of the Ca2+-independent PKC subfamily. PKCθ plays an important role in T cell activation. PKCθ is also required for the survival of activated peripheral T lymphocytes. PKCθ Recombinant Human Active Protein Kinase is a recombinant PKCθ protein that can be used to study PKCθ-related functions.
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PRKCI Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS11134PRKCI Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCI gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Bryostatin 3
0 ImagesCat. No.: HY-108602CAS No.: 143370-84-7Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion.
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Valrubicin (Standard)
0 ImagesCat. No.: HY-13772RCAS No.: 56124-62-0Synonyms: AD-32 (Standard)Valrubicin (Standard) is the analytical standard of Valrubicin. This product is intended for research and analytical applications. Valrubicin is a chemotherapy agent, inhibits TPA-and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.
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PKCζ Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70855PKCζ is a member of the atypical PKC subfamily and has been widely implicated in the regulation of cellular functions. The major activation pathway of PKCζ depends on phosphatidylinositol (PI)-3,4,5-trisphosphate (PIP(3)), which is mainly produced by PI-3 kinase. PKCζ Recombinant Human Active Protein Kinase is a recombinant PKCζ protein that can be used to study PKCζ-related functions.
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NA 0345
0 ImagesCat. No.: HY-165397CAS No.: 120925-60-2
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Ionomycin calcium (Standard)
0 ImagesCat. No.: HY-13434ARCAS No.: 56092-82-1Synonyms: SQ23377 calcium (Standard)2-(1-Piperazinyl)pyrimidine (Standard) is the analytical standard of 2-(1-Piperazinyl)pyrimidine. This product is intended for research and analytical applications. 2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558).
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PKCα Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70852PKC is a family of serine/threonine kinases involved in several processes including proliferation, differentiation, apoptosis, and migration. PKCα is a classical PKC isoform that contains a C1 domain that binds to diacylglycerol (DAG). PKCα Recombinant Human Active Protein Kinase is a recombinant PKCα protein that can be used to study PKCα-related functions.
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ICA-1S
0 ImagesCat. No.: HY-183252CAS No.: 90597-15-2
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GSK-938890A
0 ImagesCat. No.: HY-130305CAS No.: 913640-57-0GSK-938890A is a PRK1 inhibitor with an IC50 of 3600 nM. GSK-938890A is applicable to research related to prostate cancer.
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[Glu27]-PKC (19-36)
![[Glu27]-PKC (19-36)](https://file.medchemexpress.com/product_pic/hy-p1402.gif "Click to View [Glu27]-PKC (19-36) Product Detail")
0 ImagesCat. No.: HY-P1402CAS No.: 309247-49-2[Glu27]-PKC (19-36) is an inactive control for protein kinase C (PKC) (19-36). PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C, it may be responsible for maintaining the enzyme in the inactive form in the absence of allosteric activators such as phospholipids.
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AJH-836
0 ImagesCat. No.: HY-149490CAS No.: 388621-67-8
