1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Bryostatin 3

Bryostatin 3 

Cat. No.: HY-108602
Handling Instructions

Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion.

For research use only. We do not sell to patients.

Bryostatin 3 Chemical Structure

Bryostatin 3 Chemical Structure

CAS No. : 143370-84-7

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Description

Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2].

IC50 & Target

Ki: 2.75 nM (protein kinase C)[1]

In Vitro

Bryostatin 3 (1 μM; 24 h) does not inhibit [3Hlthymidine incorporation and largely blocks the growth-inhibitory action of TPA[2].
Bryostatin 3 (1 μM; 24 h) blocks the action of TPA to inhibit cell proliferation but does not block TPA-enhanced cell-substratum adhesion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

888.99

Formula

C₄₆H₆₄O₁₇

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Bryostatin 3
Cat. No.:
HY-108602
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