GSK-938890A
GSK-938890A is a PRK1 inhibitor with an IC50 of 3600 nM. GSK-938890A is applicable to research related to prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 913640-57-0
- Formula: C23H25N7O3
- Molecular Weight:447.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BT-474 | IC50 |
1040 nM
Compound: 27
|
Inhibition of GSK3-beta phosphorylation in human BT474 cells
Inhibition of GSK3-beta phosphorylation in human BT474 cells
|
[PMID: 19179070] |
| BT-474 | IC50 |
3440 nM
Compound: 27
|
Antiproliferative activity against human BT474 cells
Antiproliferative activity against human BT474 cells
|
[PMID: 19179070] |
| HFF | IC50 |
20 μM
Compound: 27
|
Antiproliferative activity against human HFF cells
Antiproliferative activity against human HFF cells
|
[PMID: 19179070] |
| LNCaP | IC50 |
176 nM
Compound: 27
|
Antiproliferative activity against human LNCAP cells
Antiproliferative activity against human LNCAP cells
|
[PMID: 19179070] |
GSK-938890A inhibits purified PRK1 with an IC50 of 3600 nM, exhibiting significantly lower potency than its stereoisomer GSK-943949A (HY-130305A)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 913640-57-0
-
Molecular Weight 447.49
-
Formula C23H25N7O3
-
SMILES
CCN1C2=CC(OC[C@H](C3=CC=CC=C3)N)=NC(C#CC(C)(O)C)=C2N=C1C4=NON=C4N
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Slynko I, et al. Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing. ChemMedChem. 2016;11(18):2084-2094. [Content Brief]
[2]. Huang H, et al. Advanced hierarchical computational modeling-based rational development of platinum (II) nanocomplex to improve lung cancer therapy. Adv Funct Mater. 2025;35(7):2411334. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-938890A Related Classifications
HY-130305 Related Classifications
Powered by Bioz