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Art. -Nr.: HY-130305

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GSK-938890A

GSK-938890A is a PRK1 inhibitor with an IC₅₀ of 3600 nM. GSK-938890A is applicable to research related to prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 913640-57-0
Formel: C₂₃H₂₅N₇O₃
Molecular Weight:447.49

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GSK-938890A Chemical Structure

CAS. Nr.: 913640-57-0

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

GSK-938890A is a PRK1 inhibitor with an IC₅₀ of 3600 nM. GSK-938890A is applicable to research related to prostate cancer^[1].

Alle PKC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	1040 nM Compound: 27	Inhibition of GSK3-beta phosphorylation in human BT474 cells Inhibition of GSK3-beta phosphorylation in human BT474 cells	[PMID: 19179070]
BT-474	IC₅₀	3440 nM Compound: 27	Antiproliferative activity against human BT474 cells Antiproliferative activity against human BT474 cells	[PMID: 19179070]
HFF	IC₅₀	20 μM Compound: 27	Antiproliferative activity against human HFF cells Antiproliferative activity against human HFF cells	[PMID: 19179070]
HFF	IC₅₀	20000 nM Compound: 27	Antiproliferative activity against human HFF cells Antiproliferative activity against human HFF cells	[PMID: 19179070]
LNCaP	IC₅₀	176 nM Compound: 27	Antiproliferative activity against human LNCAP cells Antiproliferative activity against human LNCAP cells	[PMID: 19179070]

In Vitro

GSK-938890A inhibits purified PRK1 with an IC₅₀ of 3600 nM, exhibiting significantly lower potency than its stereoisomer GSK-943949A (HY-130305A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 913640-57-0
Molecular Weight 447.49
Formel C₂₃H₂₅N₇O₃
SMILES

CCN1C2=CC(OC[C@H](C3=CC=CC=C3)N)=NC(C#CC(C)(O)C)=C2N=C1C4=NON=C4N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Slynko I, et al. Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing. ChemMedChem. 2016;11(18):2084-2094. [Content Brief]

[2]. Huang H, et al. Advanced hierarchical computational modeling-based rational development of platinum (II) nanocomplex to improve lung cancer therapy. Adv Funct Mater. 2025;35(7):2411334. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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