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Cat. No.: HY-130305A

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GSK-943949A

GSK-943949A is a PRK1 inhibitor with an IC₅₀ of 40.0 nM. GSK-943949A is applicable to research related to prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 913640-58-1
Formula: C₂₃H₂₅N₇O₃
Molecular Weight:447.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSK-943949A Chemical Structure

CAS No.: 913640-58-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

GSK-943949A is a PRK1 inhibitor with an IC₅₀ of 40.0 nM. GSK-943949A is applicable to research related to prostate cancer^[1].

All PKC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	1110 nM Compound: 26	Inhibition of GSK3-beta phosphorylation in human BT474 cells Inhibition of GSK3-beta phosphorylation in human BT474 cells	[PMID: 19179070]
BT-474	IC₅₀	2100 nM Compound: 26	Antiproliferative activity against human BT474 cells Antiproliferative activity against human BT474 cells	[PMID: 19179070]
HFF	IC₅₀	5000 nM Compound: 26	Antiproliferative activity against human HFF cells Antiproliferative activity against human HFF cells	[PMID: 19179070]
LNCaP	IC₅₀	124 nM Compound: 26	Antiproliferative activity against human LNCAP cells Antiproliferative activity against human LNCAP cells	[PMID: 19179070]

In Vitro

GSK-943949A is a small molecule that binds to AKT kinase, with an in vitro IC₅₀ value of 40.0 nM and a corresponding experimental pIC₅₀ of 7.40^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 913640-58-1
Molecular Weight 447.49
Formula C₂₃H₂₅N₇O₃
SMILES

CCN1C2=CC(OC[C@@H](C3=CC=CC=C3)N)=NC(C#CC(C)(O)C)=C2N=C1C4=NON=C4N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Slynko I, et al. Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing. ChemMedChem. 2016;11(18):2084-2094. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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