PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Acid-PEG9-NHS ester
0 ImagesCat. No.: HY-141096CAS No.: 1895916-27-4
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Benzyl-PEG5-acid
0 ImagesCat. No.: HY-138487CAS No.: 2514948-41-3
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Benzyl-PEG3-acid
0 ImagesCat. No.: HY-W096089CAS No.: 127457-63-0
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N-(Azido-PEG3)-N-Fluorescein-PEG3-acid
0 ImagesCat. No.: HY-130768CAS No.: 2100306-50-9N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties. N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG4-THP
0 ImagesCat. No.: HY-138472CAS No.: 145927-74-8Azido-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Propargyl-PEG-amine
0 ImagesCat. No.: HY-143819CAS No.: 956348-61-1
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DBCO-PEG9-DBCO
0 ImagesCat. No.: HY-140303CAS No.: 2353409-50-2
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N-PEG3-N'-(propargyl-PEG4)-Cy5
0 ImagesCat. No.: HY-141050CAS No.: 2107273-06-1N-PEG3-N'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-PEG3-N'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Dde Biotin-PEG4-Picolyl azide
0 ImagesCat. No.: HY-140917CAS No.: 2055048-42-3Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Dde Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azide-PEG16-alcohol
0 ImagesCat. No.: HY-140804Purity: 99.35%Azide-PEG16-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG16-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Br-PEG3-ethyl acetate
0 ImagesCat. No.: HY-W096139CAS No.: 308085-31-6
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Azido-PEG12-propargyl
0 ImagesCat. No.: HY-138741CAS No.: 2264091-72-5Azido-PEG12-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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t-Boc-Aminooxy-PEG7-amine
0 ImagesCat. No.: HY-140429CAS No.: 2226611-29-4
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2-Amino-1,3-bis(carboxylethoxy)propane
0 ImagesCat. No.: HY-23212CAS No.: 1020112-73-5
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Biotin-PEG2-C4-alkyne
0 ImagesCat. No.: HY-113828CAS No.: 1011268-28-2
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N-Boc-N-bis(PEG4-azide)
0 ImagesCat. No.: HY-140556CAS No.: 2055041-25-1N-Boc-N-bis(PEG4-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG4-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bromo-PEG5-CH2COOtBu
0 ImagesCat. No.: HY-144080CAS No.: 3031993-73-1
