PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Cbz-NH-PEG5-C2-acid
0 ImagesCat. No.: HY-140489CAS No.: 1347750-74-6
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Benzyl-PEG9-THP
0 ImagesCat. No.: HY-138338CAS No.: 669556-53-0
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N-(m-PEG4)-N'-(PEG4-acid)-Cy5
0 ImagesCat. No.: HY-141036CAS No.: 2107273-32-3
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Bromo-PEG2-NHS ester
0 ImagesCat. No.: HY-132018CAS No.: 2148295-96-7
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F-PEG2-SO2-COOH
0 ImagesCat. No.: HY-138495CAS No.: 3026712-13-7
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Boc-HyNic-PEG1-mal
0 ImagesCat. No.: HY-133499CAS No.: 2743657-82-9
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Azido-PEG10-CH2CO2-NHS
0 ImagesCat. No.: HY-138350Azido-PEG10-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Acid-C2-PEG3-NHS ester
0 ImagesCat. No.: HY-140011CAS No.: 1835759-79-9
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HO-PEG4-benzyl ester
0 ImagesCat. No.: HY-133316CAS No.: 2740415-11-4
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Boc-NH-PEG4-C3-acid
0 ImagesCat. No.: HY-140478CAS No.: 1416777-48-4
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1-(t-Boc-Aminooxy)-3-aminooxy-propane
0 ImagesCat. No.: HY-140405CAS No.: 1352546-80-5
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BnO-CO-O-C9-O-COOH
0 ImagesCat. No.: HY-175977CAS No.: 2669785-41-3
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m-PEG5-Tos
0 ImagesCat. No.: HY-W042501CAS No.: 80755-67-5m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277).
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TCO-PEG8-acid
0 ImagesCat. No.: HY-141161CAS No.: 2353410-03-2
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Azido-PEG6-PFP ester
0 ImagesCat. No.: HY-140772CAS No.: 1818294-47-1Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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L-Azidohomoalanine
0 ImagesCat. No.: HY-140346CAS No.: 120042-14-0L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
