PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Boc-NH-PPG2
0 ImagesCat. No.: HY-138492CAS No.: 1312905-31-9
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Acid-PEG4-S-S-PEG4-acid
0 ImagesCat. No.: HY-140114CAS No.: 2055015-40-0
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Me-Tet-PEG4-NH2 hydrochloride
0 ImagesCat. No.: HY-133505CAS No.: 2656478-51-0Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Tri(Amino-PEG4-amide)-amine
0 ImagesCat. No.: HY-140250CAS No.: 2523025-41-2
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Lipoamido-PEG4-azide
0 ImagesCat. No.: HY-130197CAS No.: 890016-39-4Lipoamido-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Lipoamido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Triethylene glycol (Standard)
0 ImagesSynonyms: PROTAC Linker 25 (Standard)
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Mal-PEG6-Boc
0 ImagesCat. No.: HY-133211CAS No.: 518044-37-6
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Aminooxy-PEG1-azide
0 ImagesAminooxy-PEG1-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Hydroxy-PEG4-methyl acetate
0 ImagesCat. No.: HY-138421CAS No.: 77303-64-1
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Boc-Pip-butyn
0 ImagesCat. No.: HY-147052CAS No.: 1346153-07-8
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Tos-PEG2-OH
0 ImagesCat. No.: HY-W090623CAS No.: 118591-58-5
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(S,R,S)-AHPC-PEG4-NHS ester
0 ImagesCat. No.: HY-W800668
