PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
Mal-PEG2-C2-Boc
0 ImagesCat. No.: HY-140964CAS No.: 1374666-31-5
-
APN-C3-PEG4-azide
0 ImagesCat. No.: HY-140841CAS No.: 2183440-32-4APN-C3-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. APN-C3-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Hydroxy-PEG5-Boc
0 ImagesCat. No.: HY-141202CAS No.: 850090-09-4
-
Desthiobiotin-PEG4-acid
0 ImagesCat. No.: HY-138507CAS No.: 2863657-56-9
-
GVSKYG-PEG2-azide hydrochloride
0 ImagesCat. No.: HY-157737AGVSKYG-PEG2-azide (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
-
Bis-propargyl-PEG7
0 ImagesBis-propargyl-PEG7 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG7 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates. Bis-propargyl-PEG7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
Aminooxy-PEG3-acid
0 ImagesCat. No.: HY-140005CAS No.: 1807540-79-9
-
Boc-NH-PEG3-propargyl
0 ImagesCat. No.: HY-140878CAS No.: 1333880-60-6
-
1,12-Dodecanediamine
0 ImagesCat. No.: HY-W014883CAS No.: 2783-17-7Synonyms: 1,12-DD; 1,12-Diamino dodecane1,12-Dodecanediamine (1,12-DD) is a reversible Maxi calcium-activated potassium channel blocker. 1,12-Dodecanediamine can reduce the single-channel current amplitude, mean channel open time, and channel open probability. 1,12-Dodecanediamine is promising for research of cell electrical signal transduction mechanism.
-
Boc-NH-PEG11-OH
0 ImagesCat. No.: HY-135947CAS No.: 1556847-53-0
-
Propargyl-PEG1-acrylate
0 ImagesCat. No.: HY-140064CAS No.: 52436-42-7
-
N-Me-N-bis-PEG4
0 ImagesCat. No.: HY-140578CAS No.: 2055046-22-3
-
Methylamino-PEG2-Boc
0 ImagesSynonyms: Methylamino-PEG2-t-butyl ester
-
THP-PEG4-OH
0 ImagesCat. No.: HY-130230CAS No.: 128660-97-9
