PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Produits associés (4102)
Produits associés (4102)
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PROTAC Linkers Isoform Comparison
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m-PEG5-succinimidyl carbonate
0 Imagesm-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
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N-Bromoacetyl-β-alanine
0 ImagesCat. No.: HY-141379CAS No.: 89520-11-6N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Propargyl-PEG4-sulfonic acid sodium
0 ImagesCat. No.: HY-140047APropargyl-PEG4-sulfonic acid sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-sulfonic acid sodium is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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HS-PEG7-CH2CH2N3
0 ImagesCat. No.: HY-130882CAS No.: 2148986-06-3HS-PEG7-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. HS-PEG7-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG3-C3-OH
0 ImagesAzido-PEG3-C3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-C3-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG8-PFP ester
0 ImagesCat. No.: HY-140773CAS No.: 2055014-62-3Azido-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl)
0 ImagesN-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Propargyl-PEG2-Tos
0 ImagesCat. No.: HY-140374CAS No.: 145916-41-2
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m-PEG9-Amine
0 ImagesCat. No.: HY-130571CAS No.: 211859-73-3m-PEG9-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG9-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Propargyl-PEG5-Br
0 ImagesCat. No.: HY-138736CAS No.: 1287660-83-6
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Fmoc-PEG1-CH2CH2-NHS ester
0 ImagesCat. No.: HY-130077CAS No.: 1807521-05-6
