2. Signaling Pathways
  3. PROTAC
  4. PROTACs
  5. MDM2 Isoform
  6. MDM2 Inhibitor

MDM2 Inhibitor

MDM2 Inhibitor (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-114312
    MD-224 2136247-12-4 99.60%
    MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 consists of ligands for Cereblon and MDM2. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent. MD-224 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    MD-224