Sirtuin
Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.
Sirtuin Isoform Specific Products
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Sirtuin Inhibitors
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Sirtuin Agonists
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Sirtuin Activators
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Sirtuin Modulators
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Sirtuin Degraders
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Sirtuin Control
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Sirtuin Substrates
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Sirtuin Ligand
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Sirtuin Related Products (319)
Related Products (319)
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Antibodies (9)
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Sirtuin Isoform Comparison
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Guttiferone G
0 ImagesCat. No.: HY-N9892CAS No.: 666174-75-0
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PROTAC Sirt2 Degrader-2
0 ImagesCat. No.: HY-179388PROTAC Sirt2 Degrader-2 is a highly efficient and selective PROTAC degrader targeting SIRT2. PROTAC Sirt2 Degrader-2 demonstrates the most potent anti-proliferative activity both in vitro and in vivo. PROTAC Sirt2 Degrader-2 leads to a marked increase in H4K16Ac levels. PROTAC Sirt2 Degrader-2 significantly suppresses clonogenic formation and migration, induces cell cycle arrest, and promotes apoptosis. PROTAC Sirt2 Degrader-2 inhibits the AKT/mTOR signaling pathway by indirectly degrading SIRT2 and blocking downstream protein phosphorylation, thereby disrupting the signaling cascade and suppressing tumor development. PROTAC Sirt2 Degrader-2 can be used for the study of ovarian cancer.
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C1A
0 ImagesCat. No.: HY-124946CAS No.: 1021463-02-4
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Nicotinamide (GMP)
0 ImagesNicotinamide (GMP) (Niacinamide (GMP)) is the GMP level of Nicotinamide (HY-B0150). GMP guidelines are used to produce Nicotinamide (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.
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YM-08
0 ImagesCat. No.: HY-139144CAS No.: 812647-88-4
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SIRT5 inhibitor 5
0 ImagesCat. No.: HY-152214CAS No.: 2883730-60-5SIRT5 inhibitor 5 is a potent SIRT5 inhibitor with an IC50 value of 0.21 µM. SIRT5 inhibitor 5 does not occupy the NNAD+ -binding pocket and acts as a substrate-competitive inhibitor.
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SIRT2-IN-12
0 ImagesCat. No.: HY-162252CAS No.: 3049202-51-6SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with a IC50 value of 50 μM.
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SIRT5 inhibitor 9
0 ImagesCat. No.: HY-149525CAS No.: 3054055-26-1SIRT5 inhibitor 9 (compound 14) is a competitive inhibitor (IC50: 4.07 μM) of sirtuin SIRT5 with anticancer potential.
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Sirt1/CXCR3-IN-1
0 ImagesCat. No.: HY-184899Sirt1/CXCR3-IN-1 is a dual Sirt1/CXCR3 inhibitor with an IC50 of 0.77 μM against Sirt1. Sirt1/CXCR3-IN-1 inhibits dengue virus replication, upregulates the expression of interferon-stimulated genes, and enhances the antiviral defense capacity of the host. Sirt1/CXCR3-IN-1 suppresses CXCR3-mediated T cell chemotaxis and cytokine release, thereby reducing immune activation and inflammatory responses. Sirt1/CXCR3-IN-1 is applicable to research related to dengue virus infection.
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SIRT6 activator 2
0 ImagesCat. No.: HY-169159CAS No.: 2867630-96-2SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases.
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Gypenoside CII
0 ImagesCat. No.: HY-N18048CAS No.: 134355-16-1
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SIRT6 activator 3
0 ImagesCat. No.: HY-182061SIRT6 activator 3 (Compound 24) is a SIRT6 activator with an EC50 of 5 μM. SIRT6 activator 3 exhibits histone deacetylation activity. SIRT6 activator 3 can be used in cancer research.
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β-Curcumene
0 Imagesβ-Curcumene is a sesquiterpene compound. β-Curcumene has the potential to act as a SIRT1 activator and a NF-κB inhibitor. β-Curcumene possesses a spicy and ginger-like aroma, and can serve as a raw material for flavors, fragrances and cosmetics. β-Curcumene can be used in the research of type 2 diabetes.
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AGK7
0 ImagesCat. No.: HY-119857CAS No.: 304896-21-7Synonyms: SIRT2 Inhibitor,Inactive Control
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Sirt1/2-IN-1
0 ImagesCat. No.: HY-146013CAS No.: 2402779-21-7
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SIRT-IN-5
0 ImagesCat. No.: HY-169051CAS No.: 3104122-36-0SIRT-IN-5 is a SIRT3 inhibitor, with an IC50 value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ.
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Sirtuin-IN-1
0 ImagesCat. No.: HY-153509CAS No.: 1392810-44-4
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Phoenixin-14 TFA
0 ImagesCat. No.: HY-P5762ASynonyms: PNX-14 TFAPhoenixin-14 (PNX-14) TFA is an endogenous neuropeptide with multiple biological activities, and serves as the endogenous ligand of GPR173. Phoenixin-14 TFA reduces ROS production by inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling axis, thereby exerting antioxidant and mitochondrial protective effects. Phoenixin-14 TFA inhibits FOXO3 phosphorylation by upregulating SIRT3 expression, suppresses apoptosis, and improves myocardial systolic/diastolic function. Phoenixin-14 TFA resists ferroptosis by activating the ATF4/SLC7A11/GPX4 axis; it activates ERK1/2 phosphorylation via GPR173. Phoenixin-14 TFA can be used in researches on neuroprotection, diabetes, cardiomyopathy, reproductive protection and so on.
