Sirtuin
Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.
Sirtuin アイソフォーム特異的製品
All Product Categories
-
Sirtuin Inhibitors
(171)
View all products
-
Sirtuin Agonists
(11)
View all products
-
Sirtuin Activators
(102)
View all products
-
Sirtuin Modulators
(12)
View all products
-
Sirtuin Inducer
(1)
View all products
-
Sirtuin Degraders
(3)
View all products
-
Sirtuin Controls
(5)
View all products
-
Sirtuin Substrates
(4)
View all products
-
Sirtuin Ligand
(1)
View all products
-
Sirtuin 関連製品 (330)
関連製品 (330)
-
抗体 (9)
-
Sirtuin Isoform Comparison
-
SIRT5 inhibitor 8
0 Images製品番号: HY-149524CAS 番号: 3054055-22-7SIRT5 inhibitor 8 (compound 10) is a competitive inhibitor (IC50: 5.38 μM) of sirtuin SIRT5 with anticancer potential.
-
SIRT5 inhibitor 6
0 Images製品番号: HY-149425CAS 番号: 2834736-82-0SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. SIRT5 Inhibitor6 has a therapeutic potential against septic AKI in vivo.
-
CypD-IN-5
0 Images製品番号: HY-116095CAS 番号: 1572646-93-5CypD-IN-5 (compound C-9) is a potent cyclophilin D (CypD) inhibitor. CypD-IN-5 can be used in the study of Alzheimer's disease.
-
Guttiferone G
0 Images製品番号: HY-N9892CAS 番号: 666174-75-0Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla.
-
PROTAC Sirt2 Degrader-2
0 Images製品番号: HY-179388CAS 番号: 3123329-68-7PROTAC Sirt2 Degrader-2 is a highly efficient and selective PROTAC degrader targeting SIRT2. PROTAC Sirt2 Degrader-2 demonstrates the most potent anti-proliferative activity both in vitro and in vivo. PROTAC Sirt2 Degrader-2 leads to a marked increase in H4K16Ac levels. PROTAC Sirt2 Degrader-2 significantly suppresses clonogenic formation and migration, induces cell cycle arrest, and promotes apoptosis. PROTAC Sirt2 Degrader-2 inhibits the AKT/mTOR signaling pathway by indirectly degrading SIRT2 and blocking downstream protein phosphorylation, thereby disrupting the signaling cascade and suppressing tumor development. PROTAC Sirt2 Degrader-2 can be used for the study of ovarian cancer.
-
C1A
0 Images製品番号: HY-124946CAS 番号: 1021463-02-4
-
Nicotinamide (GMP)
0 ImagesNicotinamide (GMP) (Niacinamide (GMP)) is the GMP level of Nicotinamide (HY-B0150). GMP guidelines are used to produce Nicotinamide (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.
-
YM-08
0 Images製品番号: HY-139144CAS 番号: 812647-88-4
-
SIRT5 inhibitor 5
0 Images製品番号: HY-152214CAS 番号: 2883730-60-5SIRT5 inhibitor 5 is a potent SIRT5 inhibitor with an IC50 value of 0.21 µM. SIRT5 inhibitor 5 does not occupy the NNAD+ -binding pocket and acts as a substrate-competitive inhibitor.
-
β-Zearalenol (Standard)
0 Images製品番号: HY-N6741RCAS 番号: 71030-11-0β-Zearalenol (Standard) is the analytical standard of β-Zearalenol (HY-N6741). This product is intended for research and analytical applications. β-Zearalenol is a zearalenone metabolite and Estrogen receptor binder (Kd = 0.406 nM) that induces apoptosis through activation of p53, JNK, and p38 kinases and the mitochondrial apoptosis pathway, while inhibiting CYP19A1 and inducing autophagy via SIRT1. β-Zearalenol is used in research on cardiotoxicity, mycotoxin-induced reproductive toxicity, and breast cancer.
-
SIRT2-IN-12
0 Images製品番号: HY-162252CAS 番号: 3049202-51-6SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with a IC50 value of 50 μM.
-
SIRT5 inhibitor 9
0 Images製品番号: HY-149525CAS 番号: 3054055-26-1SIRT5 inhibitor 9 (compound 14) is a competitive inhibitor (IC50: 4.07 μM) of sirtuin SIRT5 with anticancer potential.
-
Sirt1/CXCR3-IN-1
0 Images製品番号: HY-184899Sirt1/CXCR3-IN-1 is a dual Sirt1/CXCR3 inhibitor with an IC50 of 0.77 μM against Sirt1. Sirt1/CXCR3-IN-1 inhibits dengue virus replication, upregulates the expression of interferon-stimulated genes, and enhances the antiviral defense capacity of the host. Sirt1/CXCR3-IN-1 suppresses CXCR3-mediated T cell chemotaxis and cytokine release, thereby reducing immune activation and inflammatory responses. Sirt1/CXCR3-IN-1 is applicable to research related to dengue virus infection.
-
SIRT6 activator 2
0 Images製品番号: HY-169159CAS 番号: 2867630-96-2SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases.
-
Gypenoside CII
0 Images製品番号: HY-N18048CAS 番号: 134355-16-1Gypenoside CII is a dammarane-type triterpene saponin that can be isolated from Gynostemma pentaphyllum. Gypenoside CII exerts no significant activating effect on recombinant human Sirt1, while its congeners are potent Sirt1 agonists.
-
SIRT6 activator 3
0 Images製品番号: HY-182061SIRT6 activator 3 (Compound 24) is a SIRT6 activator with an EC50 of 5 μM. SIRT6 activator 3 exhibits histone deacetylation activity. SIRT6 activator 3 can be used in cancer research.
-
β-Curcumene
0 Imagesβ-Curcumene is a sesquiterpene compound. β-Curcumene has the potential to act as a SIRT1 activator and a NF-κB inhibitor. β-Curcumene possesses a spicy and ginger-like aroma, and can serve as a raw material for flavors, fragrances and cosmetics. β-Curcumene can be used in the research of type 2 diabetes.
