Sirtuin
Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.
Sirtuin Isoform Specific Products
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Sirtuin Inhibitors
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Sirtuin Agonists
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Sirtuin Activators
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Sirtuin Modulators
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Sirtuin Degraders
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Sirtuin Control
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Sirtuin Substrates
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Sirtuin Ligand
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Sirtuin Related Products (319)
Related Products (319)
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Antibodies (9)
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Sirtuin Isoform Comparison
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Sirtuin modulator 4
0 ImagesCat. No.: HY-148312CAS No.: 327104-77-8Sirtuin modulator 4 (compound 12) is a sirtuin modulator. Sirtuin modulator 4 shows inhibitory effect to SIRT1 with an EC50 value of 51-100 μM. Sirtuin modulator 4 may be used for the research of increasing the lifespan of a cell, and preventing a wide variety of diseases and disorders including, for example, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, inflammation and cancer.
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Resveratrol analog 2
0 ImagesCat. No.: HY-136204CAS No.: 915378-82-4Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
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SIRT1-IN-5
0 ImagesCat. No.: HY-169809CAS No.: 863589-21-3SIRT1-IN-5 (215) is a NAD-dependent protein deacetylase sirtuin-1 modulator.
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SIRT2-IN-14
0 ImagesCat. No.: HY-160617CAS No.: 1884571-59-8SIRT2-IN-14 (Compound 78) is a selectve inhibitor for SIRT2 with an IC50 of 0.196 μM.
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SIRT-IN-4
0 ImagesCat. No.: HY-163698CAS No.: 3052115-51-9SIRT-IN-4 is an inhibitor of the NAD+-dependent lysine deacetylase Sirtuin2 (Sirt2) (IC50=0.35 μM). SIRT-IN-4 is a potent Sirt2 deacetylase inhibitor that reduces cell survival and inhibits the migration of prostate cancer cells. SIRT-IN-4 can be used to study Sirt2 in cell cycle regulation, gene expression regulation, etc.
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SIRT5 inhibitor 2
0 ImagesCat. No.: HY-146386CAS No.: 340306-87-8SIRT5 inhibitor 2 (compound 49) is a potent SIRT5 inhibitor with an IC50 value of 2.3 μM. SIRT5 inhibitor 2 has inhibitory activity against the SIRT5-dependent desuccinylation. SIRT5 inhibitor 2 can be used for researching cancer and neurodegenerative diseases.
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NCO-90
0 ImagesCat. No.: HY-183870CAS No.: 1382354-18-8NCO-90 is a selective SIRT2 inhibitor with an IC50 of 1.0 μM. NCO-90 induces Apoptosis via Caspase activation and mitochondrial superoxide anion production, and also induces Autophagic cell death by increasing LC3-II levels and autophagosome accumulation. NCO-90 exhibits anticancer activity against leukemia. NCO-90 can be used in research related to acute lymphoblastic leukemia and acute myeloid leukemia.
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Antileishmanial agent-44
0 ImagesCat. No.: HY-184214Antileishmanial agent-44 is a histone deacetylase inhibitor targeting Leishmania donovani Sir2, with an IC50 of 0.652 μM against amastigotes. Antileishmanial agent-44 elevates ROS levels to induce oxidative stress, which causes mitochondrial membrane potential depolarization, cytochrome c release, phosphatidylserine externalization and DNA fragmentation, triggers apoptosis-like cell death, and arrests the cell cycle. Antileishmanial agent-44 upregulates the expression of Th1-type cytokines and NO in macrophages, reshapes host immune responses to eliminate intracellular parasites. Antileishmanial agent-44 inhibits parasites in infected golden hamsters in vivo. Antileishmanial agent-44 can be used for the research of visceral leishmaniasis.
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SIRT1 activator 4
0 ImagesCat. No.: HY-183044CAS No.: 1049800-47-6SIRT1 activator 4 is an orally active, NAD+-independent SIRT1 activator. SIRT1 activator 4 is also an analog of (E)-2'-desmethyl Sulindac (HY-B0008), with weak or negligible inhibitory activity against COX-1 and no inhibitory activity against COX-2. SIRT1 activator 4 can be used for the research of metabolic diseases.
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Altissimacoumarin F
0 ImagesCat. No.: HY-N18386CAS No.: 1384897-64-6Altissimacoumarin F (Compound 4) is a terpenylated coumarin. Altissimacoumarin F can be isolated from the stem bark of Ailanthus altissima. Altissimacoumarin F enhances SIRT1 activity, decreases p53 transcriptional activity. Altissimacoumarin F can be used for the research of age-related disorders.
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Sirtuin modulator 5
0 ImagesCat. No.: HY-148322CAS No.: 694469-31-3Sirtuin modulator 5 is a sirtuin modulating agent. Sirtuin modulator 5 can activate SIRT1 with a DC50 value of <50 μM. Sirtuin modulator 5 can be used for increasing the lifespan of a cell and used for the research of variety of diseases including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity.
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ZINC08792355
0 ImagesCat. No.: HY-126904CAS No.: 904513-52-6
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SL010110
0 ImagesCat. No.: HY-W197205CAS No.: 380173-90-0SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 degradation. SL010110 downregulates the protein level of PEPCK1 without affecting the gene expressions of PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. SL010110 significantly improves glucose homeostasis in type 2 diabetic (T2D) mice model. SL010110 can be used for T2D research.
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SRT3657
0 ImagesCat. No.: HY-136094CAS No.: 1383551-17-4SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
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SR94
0 ImagesCat. No.: HY-W841840CAS No.: 550301-63-8
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SIRT1-IN-7
0 ImagesCat. No.: HY-184372CAS No.: 720672-18-4
