2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Amylases

Amylases

Amylases are crucial enzymes which hydrolyze internal glycosidic linkages in starch and produce as primary products dextrins and oligosaccharides. Amylases are classified into α-amylase, β-amylase, and glucoamylase based on their three-dimensional structures, reaction mechanisms, and amino acid sequences. Amylases have innumerable applications in clinical, medical, and analytical chemistries as well as in food, detergent, textile, brewing, and distilling industries.

Amylases Related Products (96):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W016993
    2,3,4-Trihydroxybenzoic acid
    		Inhibitor 99.79%
    2,3,4-Trihydroxybenzoic acid is an internal standard in separation of phenolic acids by HPLC.
    2,3,4-Trihydroxybenzoic acid
  • HY-N8599
    Cichoriin
    		Inhibitor 99.9%
    Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2.
    Cichoriin
  • HY-N4309A
    Lotusine hydroxide
    		Inhibitor 99.56%
    Lotusine hydroxide is an orally active signaling pathway modulator and enzyme inhibitor, with an IC50 of 30.60 μg/mL against α-amylase and an IC50 of 36.15 μg/mL against α-glucosidase. Lotusine hydroxide inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine hydroxide induces apoptosis, triggers G0/G1 cell cycle arrest and inhibits cancer cell proliferation. Lotusine hydroxide reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine hydroxide is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder.
    Lotusine hydroxide
  • HY-149008
    α-Amylase-IN-3
    		Inhibitor 99.49%
    α-Amylase-IN-3 (Compound 4) is the inhibitor for α-Amylase, AChE and AChE with IC50s of 18.04 μM, 21.04 μM and 22.2 μM, respectively. α-Amylase-IN-3 exhibits antioxidant activity. α-Amylase-IN-3 can be used in research of diabetes and oxidative stress associated disease.
    α-Amylase-IN-3
  • HY-W112651
    2,4,6-Triphenylaniline
    		Inhibitor
    2,4,6-Triphenylaniline has anti-diabetic activity and can be encapsulated in nano-emulsions (NE) to enhance stability and permeability. The NE loaded with 2,4,6-Triphenylaniline inhibits α-glucosidase and α-amylase.
    2,4,6-Triphenylaniline
  • HY-133718
    Acarviosin
    Acarviosin, a pseudodisaccharide moiety, is a part of the potent inhibitor of α-amylase.
    Acarviosin
  • HY-N9454
    Garcinoic acid
    		Inhibitor
    Garcinoic acid is an orally active anti-inflammatory agent that crosses the blood-brain barrier. Garcinoic acid also enhances efferocytosis and enzyme/receptor regulation, and selectively inhibits human COX-2, porcine α-amylase, Saccharomyces cerevisiae α-glucosidase and human DNA polymerase β (IC50=11 μM), as well as activates human PXR. Garcinoic acid enhances macrophage efferocytosis via receptors such as MerTK and LRP-1, and promotes the production of pro-resolving lipid mediators. Garcinoic acid inhibits NF-κB activation and pro-inflammatory cytokine secretion, interferes with Aβ aggregation, downregulates NLRP3 inflammasome activity, and binds to targets including CD44 and EGFR to inhibit leukemia cell proliferation. The pharmacological activities of Garcinoic acid, such as antioxidant, anti-inflammatory and lipid metabolism-regulating effects, are widely used in studies related to various diseases including atherosclerosis, Alzheimer's disease, type 2 diabetes, inflammatory bowel disease and viral pneumonia.
    Garcinoic acid
  • HY-N4309
    Lotusine
    		Inhibitor 99.91%
    Lotusine is an orally active signaling pathway modulator and enzyme inhibitor, with an IC50 of 30.60 μg/mL against α-amylase and an IC50 of 36.15 μg/mL against α-glucosidase. Lotusine inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine induces apoptosis, triggers G0/G1 cell cycle arrest and inhibits cancer cell proliferation. Lotusine reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder.
    Lotusine
  • HY-W002011R
    Quinoline-2-carboxylic acid (Standard)
    		Inhibitor
    Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds.
    Quinoline-2-carboxylic acid (Standard)
  • HY-162373
    α-Amylase/α-Glucosidase-IN-10
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an α-amylase and α-glucosidase inhibitor (IC50: 30.39 μM and 65.1 μM) with potential diabetes inhibitory effects. α-Amylase/α-Glucosidase-IN-10 exhibits high gastrointestinal (GI) absorption in ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) prediction. While α-Amylase/α-Glucosidase-IN-10 acts as a substrate for P-gp and does not cross the blood-brain barrier (BBB), there may be a risk of central nervous system side effects.
    α-Amylase/α-Glucosidase-IN-10
  • HY-149557
    α-Amylase/α-Glucosidase-IN-5
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-5 (compound 4l) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC50s of 5.96 μM and 1.62 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity.
    α-Amylase/α-Glucosidase-IN-5
  • HY-161355
    α-Amylase/α-Glucosidase-IN-9
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-9 (compound 5h) is a dual inhibitor for both α-amylase (IC50 = 16.4 μM) and α-glucosidase (IC50 = 31.6 μM) enzymes.
    α-Amylase/α-Glucosidase-IN-9
  • HY-N12688
    2,3-Dihydrocalodenin B
    		Inhibitor
    2,3-Dihydrocalodenin B (Compound 6) is a compound that can be isolated from Knema globularia. 2,3-Dihydrocalodenin B is a potent and non-competitive inhibitor against α-glucosidase and α-amylase, with IC50 values of 1.1 and 2.6 μM, respectively. 2,3-Dihydrocalodenin B can be used for the research of diabetes.
    2,3-Dihydrocalodenin B
  • HY-169737
    Inulobiose
    		Inhibitor
    Inulobiose is a difructan disaccharide that can be isolated from Pistacia vera L.. Inulobiose inhibits α-glycosidase and α-amylase activities with IC50s of 1.87 and 40.72 mg/mL, respectively. Inulobiose can be used for the research of diabetes and glomerular filtration rate testing.
    Inulobiose
  • HY-172622
    α-Amylase/α-Glucosidase-IN-19
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase /α-glucosidase (IC50= 170.7 μM and 60.37 μM, respectively).
    α-Amylase/α-Glucosidase-IN-19
  • HY-162673
    α-Amylase/α-Glucosidase-IN-16
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-16 (compound 15) is a potent dual inhibitor of α-amylase and α-Glucosidase with IC50 values of 0.8 and 1.2 μM, respectively. α-Amylase/α-Glucosidase-IN-16 can be used in the study of diabetes mellitus (DM).
    α-Amylase/α-Glucosidase-IN-16
  • HY-156380
    α-Amylase/α-Glucosidase-IN-6
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-6 (compound 5j) is a potent dual inhibitor of α-amylase and α-glucosidase, with IC50s of 17.0 and 40.1 µM, respectively. α-Amylase/α-Glucosidase-IN-6 exhibits anti-hyperglycemic activities.
    α-Amylase/α-Glucosidase-IN-6
  • HY-168944
    ABCB1-IN-4
    		Inhibitor
    ABCB1-IN-4 (Compound C6z) is an orally active and potent dual α-amylase and α-glucosidase inhibitor with IC50 values of 1.63 μM and 0.14 μM, respectively. ABCB1-IN-4 is promising for research of diabetes.
    ABCB1-IN-4
  • HY-W727627
    5-O-Coumaroylquinic acid
    		Inhibitor
    5-O-Coumaroylquinic acid is a potent, reversible, non-competitive α-amylase inhibitor with an IC50 value of 69.39 μM. 5-O-Coumaroylquinic acid can be used in diabetes research.
    5-O-Coumaroylquinic acid
  • HY-W002011S
    Quinoline-2-carboxylic acid-d6
    		Inhibitor
    Quinoline-2-carboxylic acid-d6 is the deuterium labeled Quinoline-2-carboxylic acid (HY-W002011). Quinoline-2-carboxylic acid exhibits antidiabetic activity. Quinoline-2-carboxylic acid can be used as drug intermediate for synthesis of various active compounds.
    Quinoline-2-carboxylic acid-d<sub>6</sub>