3721-76-4
Chemical Structure
Lotusine hydroxide
- CAS No.: 3721-76-4
- Formula:C19H25NO4
- Molecular Weight:331.41
IUPAC Name: (1S,8S,10aS,Z)-8-hydroxy-1,9,10a-trimethyl-2,3,5,6,8,10a-hexahydrobenzo[8]annulen-7(1H)-one
InChIKey: WGTLSSKYFYKCNF-UNTBIKODSA-N
SMILES: C[N+]1(C)[C@H](CC2=CC=C(O)C=C2)C3=C(C=C(O)C(OC)=C3)CC1.[OH-]
Biological Activity: Lotusine hydroxide is an orally active signaling pathway modulator and enzyme inhibitor, with an IC50 of 30.60 μg/mL against α-amylase and an IC50 of 36.15 μg/mL against α-glucosidase. Lotusine hydroxide inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine hydroxide induces apoptosis, triggers G0/G1 cell cycle arrest and inhibits cancer cell proliferation. Lotusine hydroxide reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine hydroxide is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder[1][2][3][4].
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Lotusine hydroxide | 99.56% | Lotusine hydroxide is an orally active signaling pathway modulator and enzyme inhibitor, with an IC50 of 30.60 μg/mL against α-amylase and an IC50 of 36.15 μg/mL against α-glucosidase. Lotusine hydroxide inhibits the EGFR-Akt-ERK signaling pathway by reducing the levels of phosphorylated EGFR, Akt and ERK. Lotusine hydroxide induces apoptosis, triggers G0/G1 cell cycle arrest and inhibits cancer cell proliferation. Lotusine hydroxide reduces lipid peroxidation and increases the activities of SOD, CAT and GPx. Lotusine hydroxide is applicable to researches related to non-small cell lung cancer, type 2 diabetes and autism spectrum disorder. | ||||||||||||||||||||
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- [1]. Lan Y, et al. Anti-lung cancer activity of lotusine in non-small cell lung cancer HCC827 via reducing proliferation, oxidative stress, induction of apoptosis, and G0/G1 cell cycle arrest via suppressing EGFR-Akt-ERK signalling. In Vitro Cell Dev Biol Anim. 2025;61(4):450-458. [Content Brief]
- [2]. Nahed S. Alharthi, et al. Prophylactic Impacts of Lotusine Against Hyperglycaemia-Induced Oxidative Stress in Hepatic Cells Isolated from Diabetic Rats Via Irs-1/Pi3 K/Akt Pathway. Pak Vet J, 45(1): 124-137.
- [3]. Harishkumar R, et al. Lotusine, an alkaloid from Nelumbo nucifera (Gaertn.), attenuates doxorubicin-induced toxicity in embryonically derived H9c2 cells. In Vitro Cell Dev Biol Anim. 2020;56(5):367-377. [Content Brief]
- [4]. Liu QQ, et al. Lotusine ameliorates propionic acid-induced autism spectrum disorder-like behavior in mice by activating D1 dopamine receptor in medial prefrontal cortex. Phytother Res. 2024;38(2):1089-1103. [Content Brief]
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