Apolipoprotein
Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III. Specific apolipoproteins function in the regulation of lipoprotein metabolism through their involvement in the transport and redistribution of lipids among various cells and tissues, through their role as cofactors for enzymes of lipid metabolism, or through their maintenance of the structure of the lipoprotein particles.
Apolipoprotein Isoform Specific Products
All Product Categories
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Apolipoprotein Related Products (88)
Related Products (88)
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Apolipoprotein Isoform Comparison
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Lp(a)-IN-5
0 ImagesCat. No.: HY-171464CAS No.: 2924841-79-0Lp(a)-IN-5 (Compound A) is an orally active lipoprotein (a) (Lp(a)) inhibitor. Lp(a)-IN-5 inhibits the assembly of Apo(a) and ApoB proteins with an IC50 value of 0.41 nM. Lp(a)-IN-5 is promising for research of diseases related to elevated plasma Lp(a) levels, such as cardiovascular diseases.
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1-Linoleoyl Glycerol (Standard)
0 ImagesCat. No.: HY-111346RCAS No.: 2277-28-3Synonyms: 1-Linoleoyl-rac-glycerol (Standard); 1-Monolinolein (Standard)1-Linoleoyl Glycerol (Standard) is the analytical standard of 1-Linoleoyl Glycerol. This product is intended for research and analytical applications. 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6).
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PLTP-IN-1
0 ImagesCat. No.: HY-179364CAS No.: 1224565-08-5PLTP-IN-1 (cpd B) is a selective phospholipid transfer protein (PLTP) inhibitor with an IC50 of 1.6 μM. PLTP-IN-1 can block the phospholipid transfer mediated by PLTP and reduce the secretion of apolipoprotein B. PLTP-IN-1 has no effect on the level of triglycerides. PLTP-IN-1 can be used for the research of metabolic disease, such as hyperlipidemia.
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Apoa4 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS19408Apoa4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoa4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
Apoa4 siRNA-1: 5 nmol (HPLC)
Apoa4 siRNA-2: 5 nmol (HPLC)
Apoa4 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
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Terbufibrol (Standard)
0 ImagesCat. No.: HY-101812RCAS No.: 56488-59-6Terbufibrol (Standard) is the analytical standard of Terbufibrol (HY-101812). This product is intended for research and analytical applications. Terbufibrol is an orally active lipid-lowering agent. Terbufibrol inhibits hepatic Cholesterol 7 alpha-hydroxylase. Terbufibrol blocks a step between Acetate and HMG-CoA in the hepatic cholesterol synthesis process. Terbufibrol reduces serum total cholesterol, HDL, LDL, lipoprotein levels, and the cholesterol/phospholipid ratio, with dose- and sex-dependent changes in lipoprotein components. Terbufibrol exerts sustained cholesterol-lowering activity in baboons and rats. Terbufibrol can be used in research related to hypercholesterolemia.
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Apoa2 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS19983Apoa2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoa2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
Apoa2 siRNA-1: 5 nmol (HPLC)
Apoa2 siRNA-2: 5 nmol (HPLC)
Apoa2 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
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EZ-482 (Standard)
0 ImagesCat. No.: HY-103076RCAS No.: 1016456-76-0EZ-482 (Standard) is the analytical standard of EZ-482 (HY-103076). This product is intended for research and analytical applications. EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas.
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Tisbesiran
0 ImagesCat. No.: HY-185932CAS No.: 2959546-45-1Tisbesiran is an apolipoprotein(a) (apo(a)) synthesis inhibitor. Tisbesiran is a trivalent GalNAc-conjugated double-stranded siRNA with a mixed modification of 2′-OMe/2′-F/P-thio. Its antisense strand targets the KIV-2 repeat region of human apo(a) (LPA) mRNA, thereby inhibiting apolipoprotein(a) synthesis and reducing plasma Lp(a). Tisbesiran can be used for research on Lp(a)-mediated atherosclerotic cardiovascular disease.
