Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4032)
Related Products (4032)
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Canthic acid
0 ImagesCat. No.: HY-N17285CAS No.: 23423-86-1Canthic acid is a natural product that can be found in Styrax benzoin.
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Hydroxysaikosaponin D
0 ImagesCat. No.: HY-N17882ACAS No.: 173559-75-6Hydroxysaikosaponin D is a hepatocytoprotective saponin found in the roots of Bupleurum scorzonerifolium WILLD. Hydroxysaikosaponin D inhibits D-galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Hydroxysaikosaponin D mitigates D-galactosamine/LPS-induced liver injury in mice. Hydroxysaikosaponin D can be used for the research of liver injury.
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(Z-AR)2Rh110
0 ImagesCat. No.: HY-P11476CAS No.: 88064-36-2(Z-AR)2Rh110 is a Rhodamine derivative. (Z-AR)2Rh110 can be hydrolyzed by trypsin.
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N-(2-Chlorophenyl)-1H-indole-3-carboxamide
0 ImagesCat. No.: HY-121682CAS No.: 61788-27-0N-(2-Chlorophenyl)-1H-indole-3-carboxamide (Compound 60) is a substituted derivative of the pyrazolo[1,5-a]pyridine core. N-(2-Chlorophenyl)-1H-indole-3-carboxamide does not exhibit EphB3 kinase inhibitory activity and can be used as a negative control compound.
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Tinoscorside D
0 ImagesCat. No.: HY-N16855CAS No.: 1257394-29-8Tinoscorside D is a natural phenylacetylene.
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N-Deacetylcolchicine tartrate
0 ImagesCat. No.: HY-121434ACAS No.: 49720-72-1N-Deacetylcolchicine tartrate is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine tartrate is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine tartrate can activate the GTPase activity of microtubules and can be used for the research of cancer.
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Pimilprost
0 ImagesCat. No.: HY-106893CAS No.: 139403-31-9Synonyms: SM 10902Pimilprost (SM 10902) is a prostaglandin I1 analogue. Pimilprost exhibits antithrombotic and increases cAMP levels. Pimilprost can promote wound healing through the stimulation of angiogenesis and the improvement of blood flow in diabetic mice. Pimilprost can be used for the research of metabolic and cardiovascular disease, such as diabetes.
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Antitumor agent-189
0 ImagesCat. No.: HY-168587Antitumor agent-189 (Compound DN4) is a potent antitumor agent, and a 4-oxobutanamide derivative. Antitumor agent-189 inhibits A498 cells proliferation, adhesion and invasion with an IC50 of 1.94 μM. Antitumor agent-189 also inhibits angiogenesis and tumor growth in the xenograft model of A498 cells.
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PDK1/AurA-IN-1
0 ImagesCat. No.: HY-124288CAS No.: 1919884-11-9PDK1/AurA-IN-1 is an active compound.
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1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard)
0 ImagesCat. No.: HY-W016194RCAS No.: 67950-95-2Synonyms: 1-Carboxycyclohexaneacetic acid (Standard); Gabapentin Impurity E (Standard); Gabapentin Related Compound E (Standard)1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) (1-Carboxycyclohexaneacetic acid (Standard); Gabapentin Impurity E (Standard); Gabapentin Related Compound E (Standard)) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid (HY-W016194). This product is intended for research and analytical applications. 1-(Carboxymethyl) cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E; Gabapentin Related Compound E) is a succinic acid and a potential impurity in the synthesis of Gabapentin (HY-A0057), and it can be used in studies related to organic synthesis.
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Jingsongling
0 ImagesCat. No.: HY-118390CAS No.: 25332-05-2Jingsongling is a Xylazine analog and anesthetic agent. Jingsongling causes bradycardia and hypertension by mediating α2-adrenoceptors. Jingsongling inhibits canine gastric motility through mediation of α1 and α2 adrenergic receptors.
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16α-O-Methylneoquassin
0 ImagesCat. No.: HY-N17061CAS No.: 89498-94-216α-O-Methylneoquassin is a natural diterpene.
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Naringenin 7-O-β-D-glucuronide methyl ester
0 ImagesCat. No.: HY-W749337CAS No.: 1985597-72-5Naringenin 7-O-β-D-glucuronide methyl ester is a natural flavonoid.
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2β,15α-Dihydroxy-ent-kaur-16-ene
0 ImagesCat. No.: HY-N17014CAS No.: 34302-36-82β,15α-Dihydroxy-ent-kaur-16-ene is a natural diterpene.
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Isolimonic acid
0 ImagesCat. No.: HY-N17108CAS No.: 74729-97-8Isolimonic acid is a natural triterpene.
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Antileishmanial agent-45
0 ImagesCat. No.: HY-189345Antileishmanial agent-45 is a C6-substituted eugenol derivative bearing a 1,2,3-triazole linker directly attached to the aromatic ring, a free phenolic hydroxyl group, and a benzyloxy substituent. Antileishmanial agent-45 retains and enhances the antileishmanial activity of its natural-product precursor eugenol. Antileishmanial agent-45 can be used for the research of leishmaniasis.
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Isoscutellarein 8-O-glucoside
0 ImagesCat. No.: HY-N17116CAS No.: 53761-83-4Isoscutellarein 8-O-glucoside is a natural flavonoid.
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Dehydropinifolic acid
0 ImagesCat. No.: HY-N17479CAS No.: 33123-07-8Dehydropinifolic acid is a natural product that can be found in Forsythia suspensa?(Thunb.) Vahl.
